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Salt Intake and Inflammatory Skin Disease Study

This study is looking at how salt intake affects skin sodium levels and inflammatory skin conditions like atopic dermatitis (eczema) and psoriasis. Researchers want to see if changing your diet's salt content can improve these conditions. You would receive either sodium chloride tablets or placebo tablets (inactive pills) to see their effects. The main goals are to see if this type of study is possible to run, how many people join and stay in the study, and if a low-salt diet can improve skin conditions. This study is open to adults aged 18 and older who are willing and able to have an MRI. The study status is currently unclear.

Study design
This is an interventional study planning to enroll 50 participants, including those with atopic dermatitis, psoriasis, and healthy individuals. Participants will be randomized to receive either sodium chloride tablets or placebo tablets in a crossover design.
What's involved
Participants with atopic dermatitis and psoriasis will follow a low-sodium diet for 13 weeks and take daily tablets for two 5-week periods, separated by a 2-week break. You will also undergo non-contrast MRI scans.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints for the study are measured at 4 months.

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NCT07487831

The Impact of Salt Intake on Sodium in the Skin and Inflammatory Skin Disease

Not Yet Recruiting
PHASE4Ages 18+InterventionalPrevention
University of California, San Francisco
~50 participants
Updated 2026-06-09 on ClinicalTrials.gov
What's tested:Sodium chloride tabletsPlacebo Tablets

At a glance

Recruiting sites
0 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Fidelity of low-salt diet
Measured over 4 months
+2 more outcomes measured

Conditions

Atopic Dermatitis (Eczema)
Psoriasis

Explore related trials

Atopic DermatitisPsoriasis

Where it's being run

2 sites across 1 states
California2

Study leadership

  • Katrina Abuabara, MD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco

Who to contact

Alicia Hamblin
[email protected]
925-549-7889
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Participants ages 18 years
Willing and able to undergo non-contrast MRI.

Exclusion

Contraindications to MRI (such as cardiac pacemakers, claustrophobia, non-compatible intracranial vascular clips, IUDs, or other implants)
A cardiac event in the past 6 months
Impaired function of the liver or kidney (glomerular filtration rate \<60 mL/min)
Medications that influence sodium excretion (e.g., diuretics or SGLT2 inhibitors)
Antibiotic or immunomodulatory medications within the last month
Contraindications to sodium tablets

What this trial measures

  • Fidelity of low-salt diet4 months

    Fidelity of the low-salt diet and sodium tab intervention adherence will be assessed based on sodium levels from food recall questionnaires and 24-hour urine sodium samples.

  • Feasibility measured by recruitment rates and exclusion and non-participation reasons4 months

    To assess feasibility, recruitment rates will be calculated and reasons for exclusion and non-participation will be summarized using descriptive statistics.

  • Retention rates4 months

    Retention rates will be calculated as the proportion of visits completed and will be compared by study arm and participant characteristics.