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Pilot Study of Platelet Rich Plasma for Knee Osteoarthritis

This study is looking at two different ways to prepare Platelet Rich Plasma (PRP) for people with knee osteoarthritis (a condition where the cartilage in your knee wears down). The researchers want to see if PRP made by the Emcyte PurePRP Supraphysiologic Concentrating System is different in quality or how it works compared to PRP made by the APEX Biologix XCELL PRP System. Both systems are FDA-approved. You might be able to join if you are 18 or older, have mild to moderate knee osteoarthritis symptoms for at least 3 months, and can attend physical therapy. The main goal is to compare the cells in the PRP from both systems. The study aims to enroll 20 participants, but its current status is unclear.

Study design
This is an interventional study comparing two different methods of preparing Platelet Rich Plasma (PRP). It plans to enroll 20 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, cellular composition and quantity, is measured at Day 1.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07491367

Pilot Exploration of Platelet Characterization of Platelet Rich Plasma Created by Two Different Systems

Recruiting
PHASE4Ages 18+InterventionalBasic science
University of California, San Francisco
~20 participants
Updated 2026-08-18 on ClinicalTrials.gov
What's tested:Platelet Rich PlasmaEmcyte PurePRP Supraphysiologic Concentrating SystemAPEX Biologix XCELL PRP System

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Cellular composition and quantity using Horiba Cell counter
Measured over Day 1

Conditions

Knee Osteoarthristis
Cartilage Damage
Platelet Rich Plasma
Platelet Rich Plasma Injection

Explore related trials

Cartilage DamageOsteoarthritis of knee

NCT07491367

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of California San Francisco

    San Francisco, Californiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Anthony Luke, MD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco

Who to contact

Joel Kopcow
[email protected]
970-590-0314
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Kellgren-Lawrence (KL) Grade 1-3 knee osteoarthritis
Symptoms of knee osteoarthritis for at least 3 months before presentation in one knee
Will be able to attend and perform physical therapy

Exclusion

Received injection therapy for knee osteoarthritis in the past 6 months
Have severe arthritis diagnosed in ≥1 major joint by radiology criteria
History of septic arthritis
Underwent knee surgery for osteoarthritis or osteochondral defects within 1 year before randomization (e.g., autograft or allograft surgery)
Have had high tibial osteotomy, partial knee replacement, patellar resurfacing, total knee replacement, or have existing surgical hardware in the knee
Received a platelet-rich plasma injection elsewhere in the body within the past 3 months
Have a platelet disorder or bleeding disorder
Have a rheumatologic disease, autoimmune disorder, immunocompromised status, or active history of cancer
Are taking chemotherapy, require regular prednisone, or require regular anti-inflammatory use
Are pregnant, breastfeeding, or unwilling to practice birth control during the study
If both knees have osteoarthritis and the other knee has KL score equal to or greater than 2.
Have uncontrolled illness, physical disability, or other contraindication to aerobic exercise training

What this trial measures

  • Cellular composition and quantity using Horiba Cell counterDay 1

    Compare cellular composition and quantifying PRP products between EmCyte PurePRP versus APEX Biologix XCELL PRP manufacturing systems using a Horiba Cell counter.