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Precision Rehabilitation for Veterans With Heart Failure with Preserved Ejection Fraction (HFpEF)

This observational study is looking into how monitored exercise during cardiac rehabilitation might help Veterans with heart failure with preserved ejection fraction (HFpEF). HFpEF means your heart can pump blood, but it's stiff and doesn't fill properly. Researchers want to see if a facility can support a larger study on this topic and if exercise is beneficial, not harmful, for these patients. They will measure your cardiorespiratory fitness (how well your heart and lungs work during exercise) at 12 weeks. To join, you must be an adult with New York Heart Association Class II or III HF symptoms, a history of high blood pressure, an ejection fraction (EF) of 50% or more, and evidence of left ventricular hypertrophy (thickening of the heart's main pumping chamber) and diastolic dysfunction (problems with the heart filling with blood). This study is currently unclear on its status and plans to enroll 4 participants.

Study design
This is an observational study, meaning researchers will collect information without giving specific interventions. It plans to include 4 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your cardiorespiratory fitness will be measured at 12 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07493915

Precision Rehabilitation for Veterans With (HFpEF)

Recruiting
Not specifiedAges 18+Observational
Columbia VA Health Care System
~4 participants
Updated 2026-03-25 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Cardiorespiratory Fitness (CRF)
Measured over 12 Weeks

Conditions

Heart Failure
Preserved Ejection Fraction

Explore related trials

Heart failure with normal ejection fraction

Where it's being run

1 sites across 1 states
South Carolina1

Study leadership

  • Kurt Barringhaus, MD, FACC, FSCAI · PRINCIPAL_INVESTIGATOR · William Jennings Bryan Dorn VA Medical Center

Who to contact

Kurt Barringhaus, MD, FACC, FSCAI
[email protected]
803-776-4000 · ext. 54106
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

New York Heart Association Class II or III HF symptoms
History of hypertension
EF≥50%
LVH confirmed by echocardiography, Cardiac CT, or Cardiac MR
Diastolic dysfunction which must include ≥2 of the following:
Ability to participate in an exercise program as determined by a research, cardiology, or primary care provider

Exclusion

Ejection Fraction \< 50%
Absence of LVH
LV Dilation (LV end diastolic volume indexed to BSA \> 75 ml/m2)
Any Segmental wall motion abnormality
Acute ST segment elevation myocardial infarction (STEMI)
Significant valvular or other non-coronary heart disease
Any non-cardiac disease or condition that could influence myocardial function (e.g., collagen-vascular disease, history of cardiotoxic cancer chemotherapy, amyloid)
Anemia defined as Hgb \< 11.0 g/dl in males, 10 g/dl in females
Current accelerating angina, unstable angina, angina at rest, or NSTEMI within 3 months
Chronic pulmonary disease requiring home oxygen or steroid therapy
Significant non-CV organ disease: Chronic hepatic or renal disease (eGFR \< 25 mL/min/1.73m2)
Inability to provide informed consent
Inability to perform exercise

What this trial measures

  • Cardiorespiratory Fitness (CRF)12 Weeks

    Change in cardiorespiratory fitness response (\>10% increase in oxygen consumption on cardiopulmonary exercise testing).