Sleep Loss and Insulin Resistance Study
This study is looking at how sleep loss affects insulin resistance (when your body's cells don't respond well to insulin, a hormone that helps control blood sugar). Researchers want to understand if changing cortisol (a stress hormone) levels can prevent insulin resistance caused by not getting enough sleep. You might receive Metyrapone and Hydrocortisone to control your cortisol levels, and Dextrose and insulin as part of a test to measure your body's response to sugar. The study aims to see if these interventions change your insulin resistance, measured by specific tests. They are looking for 48 healthy men and women between 18 and 45 years old with a stable weight. The current status of recruitment is unclear.
- Study design
- This is an interventional study planning to enroll 48 participants. The study involves giving participants specific medications to understand their effects.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Insulin resistance will be measured at change from baseline collection, but the duration of follow-up is not specified.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Peter Liu, MBBS, PhD · PRINCIPAL_INVESTIGATOR · Lundquist Institute of Biomedical Innovation at Harbor-UCLA Medical Center
- Hans P.A. Van Dongen, PhD · PRINCIPAL_INVESTIGATOR · Washington State University
Who to contact
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What this trial measures
- Insulin resistance-Minimal Model (Si)Change from baseline collection.
Insulin resistance-minimal model (Si) will be measured from the frequently sampled intravenous glucose tolerance test (FSIVGTT) and reflects glucose disposal rate during the insulin response. it will be calculated as the change from baseline (by subtraction).
- Insulin Resistance-Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)Change from baseline collection.
The Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) will be measured from the frequently samples intravenous glucose tolerance test (FSIVGTT) and reflects the fasting insulin resistance. It will be calculated as the change from baseline (by subtraction).
- Insulin Resistance-Insulin Sensitivity Index (Mi)Change from baseline collection.
The Insulin Sensitivity Index (Mi) will be measured from the frequently sampled intravenous glucose tolerance test (FSIVGTT). Si is calculated using the minimal model and measures whole-body insulin sensitivity. It will be calculated as the change from baseline (by subtraction).