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IMAGES: Genicular Artery Embolization for Knee Osteoarthritis

This study, called IMAGES, is looking at how a procedure called genicular artery embolization (GAE) affects knee osteoarthritis. GAE is a treatment for knee pain. Researchers want to see if changes in your body's metabolic activity (how your body uses energy), measured by special scans (PET/MRI), can predict how well GAE will work for you. They are trying to understand why some people benefit a lot from GAE and others don't. You might be able to join if you are at least 40 years old, have moderate to severe knee pain from osteoarthritis, and haven't found relief from other treatments or can't have surgery. The study plans to enroll 25 participants. The main goal is to compare your metabolic activity before GAE and 6 months after.

Study design
This is an interventional study planning to enroll 25 participants. It is not specified if it is randomized or blinded.
What's involved
You would undergo genicular artery embolization. You would also have metabolic activity measured at screening and again at 6 months.
Compensation
Not stated in the trial record.
Follow-up
Your metabolic activity will be measured at 6 months after the procedure.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07494838

IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success

Not Yet Recruiting
NAAges 40+InterventionalDiagnostic
Lucas R. Cusumano, MD
~25 participants
Updated 2026-08-19 on ClinicalTrials.gov
What's tested:Embolization

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Compare metabolic activity
Measured over Screening, Month 6

Conditions

Knee Osteoarthritis
Knee Discomfort
Knee Pain Chronic
Knee Swelling Pain

Explore related trials

Osteoarthritis of knee

NCT07494838

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of California, Los Angeles

    Los Angeles, Californiastudy coordinator listed

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Lucas Cusumano, MD · PRINCIPAL_INVESTIGATOR · University of California, Los Angeles

Who to contact

Arshia Mian, BS
[email protected]
310-906-6028
Email the study team

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Eligibility criteria

Inclusion

Provided informed consent
Age ≥ 40 years
Ineligibility for or refusal of surgical management
Moderate-severe knee pain as determined by visual analog scale \> 5 out of 10
Osteoarthritis based on X-ray. Kellgren-Lawrence score \> 2 based on radiograph completed within 3 months of procedure date
Resistant/failed some form of conservative treatment (e.g. NSAIDS/physical therapy/steroid joint injection/hyaluronic acid joint injection) for at least 3 months
Able to comply with all treatments and protocol follow-up visits

Exclusion

Mild knee pain as determined by visual analog scale \< 5 out of 10
OA on knee radiograph resulting in greater than 20 degree varus or valgus angulation
Moderate loss of kidney function, define as estimated glomerular filtration rate of less than 45 mL/min.
Significant arterial atherosclerosis that would limit selective angiography
History of fibromyalgia, autoimmune, or inflammatory disorder
History of any lumbar spine surgery, spine injections, or radicular pain in the extremity believed to originate from the spine
Allergy to iodinated contrast agents
Active infection or malignancy
Recent (within 12 months) or active cigarette use
Prior total or partial knee replacement in the subject knee
Active pregnancy
Uncorrectable bleeding diathesis
Presence of pacemakers, aneurysm clips, neurostimulators, or any other metal implant not compatible with PET/MRI

What this trial measures

  • Compare metabolic activityScreening, Month 6

    To compare change in metabolic activity detected by PET/MRI as defined as percentage change in maximum standardized uptake value (SUVmax) and incidence of clinical response in patients undergoing GAE as defined as a 50% reduction in Western Ontario and McMaster Universities Arthritis Index (WOMAC).