Siemens Biomarker Multi-modality Study for Fatty Liver

This study is looking at how well new imaging technologies, Photon-counting CT (PCCT) and Ultrasound, can find fat and scarring in the liver. These results will be compared to Magnetic Resonance Imaging (MRI), which is considered the standard. You would receive a regular CT scan using the PCCT scanner, plus a few extra pictures for the study. You would also have an MRI and an Ultrasound. If needed, you might also have a blood test. This study is for adults aged 18 or older with certain liver conditions who are already scheduled for a CT scan of the liver and are eligible for MRI. The study aims to see how accurate PCCT and Ultrasound are at detecting liver fat within 1 to 14 days.

Study design
This is an interventional study planning to enroll 45 participants. It compares different imaging techniques to a standard MRI.
What's involved
You would undergo a Photon-counting CT scan, an MRI, and an Ultrasound. You might also have a blood test if you haven't had one recently.
Compensation
Not stated in the trial record.
Follow-up
The study measures the accuracy of the imaging tests within 1 to 14 days.

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NCT07495332

Siemens Biomarker Multi-modality

Recruiting
NAAges 18+InterventionalDiagnostic
Duke University
~45 participants
Updated 2026-04-03 on ClinicalTrials.gov
What's tested:Photon-counting CT (PCCT)UltrasoundMagnetic Resonance Imaging (MRI)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Sensitivity of CT-FF (computed tomography fat fraction)
Measured over 1 day to 14 days
+1 more outcome measured
Fatty Liver
Hepatic Steatosis
1 sites across 1 states
North Carolina1
  • Mustafa Bashir, MD · PRINCIPAL_INVESTIGATOR · Duke University

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age of 18 years or older
Has clinically indicated CT schedule including the liver (with contrast or with and without contrast)
Patient eligible for MR imaging
History of chronic diffuse liver disease, steatotic liver disease, and/ or liver fibrosis
Capable of consent

Exclusion

Contraindications to any of the required imaging examinations
BMI \> 45 (based on MRI scanner capacity)
  • Sensitivity of CT-FF (computed tomography fat fraction)1 day to 14 days

    The percentage of patients with hepatic steatosis by MRI-PDFF who have positive CT-PDFF.

  • Specificity of CT-FF (computed tomography fat fraction)1 day to 14 days

    The percentage of patients without hepatic steatosis by MRI-PDFF who have negative CT-PDFF.