Travoprost Implant for Glaucoma or Ocular Hypertension

This study is testing a new way to treat glaucoma (a group of eye conditions that damage the optic nerve) or ocular hypertension (high pressure inside the eye). It's comparing a second-generation Travoprost Intracameral Implant to Timolol eye drops 0.5%. The implant is a small device placed in the eye that releases the drug Travoprost. Researchers want to see how safe and effective the implant is at lowering eye pressure. You might be able to join if you are 18 or older and have open-angle glaucoma or ocular hypertension in the eye being studied. The main goal is to measure your eye pressure after 3 months.

Study design
This interventional study plans to enroll 510 participants. It compares the Travoprost implant to Timolol eye drops, a sham procedure, or placebo eye drops.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your eye pressure will be measured at 3 months to see how well the treatment worked.

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NCT07495852

Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant

Recruiting
PHASE3Ages 18+InterventionalTreatment
Glaukos Corporation
~510 participants
Updated 2026-03-30 on ClinicalTrials.gov
What's tested:Gen 2 Travoprost Intracameral ImplantTimolol eye drops 0.5%Sham Procedureplacebo eye drops

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Intraocular pressure (IOP)
Measured over 3 months
Glaucoma
1 sites across 1 states
Alabama1

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Eligibility criteria

Inclusion

Diagnosis of Ocular Hypertension or Open-Angle Glaucoma in the study eye

Exclusion

Prior incisional glaucoma surgery in the study eye
Prior argon laser trabeculoplasty (ALT) in the study eye
Prior minimally invasive glaucoma (MIGS) surgery in the study eye
  • Intraocular pressure (IOP)3 months

    Change from baseline in diurnal IOP in the study eye at 8am and 10am at each of Day 11, Week 6, and Month 3 visits