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Brain Effects of Gamma Frequency Sensory Stimulation for Cognitively Healthy People and Alzheimer's Disease

This study is exploring how special light, sound, and tactile (touch) devices, called GENUS and Tactile GENUS, affect brain activity. Researchers want to see if these devices, which deliver stimulation at a specific 40Hz frequency, can change brain waves. This is important because changes in these brain waves (gamma oscillations) are linked to Alzheimer's disease. The study aims to see if these devices are safe and if they can impact brain connections, memory and thinking skills, and even blood markers. You might be able to join if you are between 18 and 100 years old, have good vision and hearing, and can complete study tests. The goal is to understand if this non-invasive approach could help with cognitive (thinking) problems.

Study design
This is an interventional study with a planned enrollment of 150 participants. It is not specified if it is randomized or blinded.
What's involved
Participants will come to MIT for a single 1-day visit. During this visit, you may undergo tests like EEG (brain wave measurement), MEG (another brain wave measurement), MRI (brain imaging), neuropsychological testing, and blood sampling.
Compensation
Not stated in the trial record.
Follow-up
The primary effects on brain oscillations will be measured at 1 year.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07496918

Brain Effects of Gamma Frequency Sensory Stimulation (40Hz Light, Sound and Other Devices)

Recruiting
PHASE2Ages 18+InterventionalTreatment
Massachusetts Institute of Technology
~150 participants
Updated 2026-03-27 on ClinicalTrials.gov
What's tested:GENUSTactile GENUS

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Effects of GENUS on brain oscillations
Measured over 1 year
+2 more outcomes measured

Conditions

Cognitively Healthy People
Alzheimer Disease

Explore related trials

Alzheimer's DiseaseCognitively Healthy People

Where it's being run

1 sites across 1 states
Massachusetts1

Study leadership

  • Ana Trisini Lipsanopoulos, BS · STUDY_DIRECTOR · Massachusetts Institute of Technology

Who to contact

gamma wave
[email protected]
617-258-7723
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Have adequate visual and auditory acuity for visual and auditory stimulation to allow for neuropsychological testing.
Be able to comply with neuropsychological testing and other study procedures in opinion of site PI.

Exclusion

History of seizure or medical diagnosis of epilepsy.
Have MRI contraindications, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body.
Under the discretion of the site investigator, the site investigator feels the subject cannot complete sufficient key study procedures. Exceptions to these guidelines may be considered on a case-by-case basis at the discretion of the Project Director.

What this trial measures

  • Effects of GENUS on brain oscillations1 year

    Using Electroencephalogram (EEG), investigators will determine whether GENUS will affect brain oscillations, including those in the gamma band.

  • Effects of GENUS on brain oscillations1 year

    Using Magnetoencephalography (MEG), investigators will determine whether GENUS will affect brain oscillations.

  • Effects of GENUS on brain oscillations1 year

    Using magnetic resonance imaging (MRI), investigators will determine whether GENUS will affect brain oscillations.