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Smart Virtual Reminiscence Therapy for Older Adults with Dementia

This study is testing a new approach called Smart Virtual Reminiscence (SVR) therapy for older adults with mild cognitive impairment (MCI) or mild Alzheimer's Disease and Related Dementias (ADRD). SVR therapy uses a computer program with a virtual therapist to help improve psychological well-being and thinking skills. The study aims to see if SVR therapy can reduce behavioral and psychological symptoms of dementia (BPSD), such as agitation or depression. You might be able to join if you are 65 or older, have MCI or mild ADRD, have internet access, live at home, and have elevated BPSD. The study will compare SVR therapy to listening to calming music. We don't know the current recruitment status.

Study design
This is an interventional study planning to enroll 60 participants. Participants will be randomly assigned to either receive SVR therapy or listen to music.
What's involved
Participants will receive SVR therapy or listen to music twice a week for 12 weeks. Their BPSD will be measured at the start and after 3 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for approximately 3 months to track hospitalizations and emergency visits.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07499570

Multi-modal Large Language Model-Empowered Talk Therapy for Older Adults With ADRD

Recruiting
NAAges 65+InterventionalTreatment
Indiana University
~60 participants
Updated 2026-05-06 on ClinicalTrials.gov
What's tested:Smart Virtual Reminiscence TherapyMusic Therapy

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Reduction in BPSD as measured by the Neuropsychiatric Inventory (NPI) total score
Measured over Baseline and Month 3
+1 more outcome measured

Conditions

Mild Cognitive Impairment
Dementia
BPSD
BPSD (Behavioral and Psychological Symptoms of Dementia)
Reminiscence Therapy

Explore related trials

Alzheimer's Disease and Related DementiasBehavioral and psychological symptoms of dementiaMild cognitive disorder

NCT07499570

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Sidney & Lois Eskenazi Hospital

    Indianapolis, Indianastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Malaz Boustani, MD, MPH · PRINCIPAL_INVESTIGATOR · Indiana University

Who to contact

Katrina Coppedge, BA
[email protected]
317-278-1602
Email the study team

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Eligibility criteria

Inclusion

age ≥ 65 years
diagnosis of MCI (mild cognitive impairment) or mild ADRD
access to a reliable internet connection
community-dwelling
elevated behavioral and psychological symptoms of dementia (BPSD), indicated by a HABC (Healthy Aging Brain Care) monitor score above 14 on caregiver report or self report (indicating elevated levels of BPSD)
presence of one or more specific BPSD behaviors (e.g., agitation, anxiety, depression, apathy, or sleep disturbances)
ability to consent for themselves.
≥ 21 years old
self-identified care partner (e.g., is knowledgeable about the patient's daytime and nighttime behaviors) of a community-dwelling patient diagnosed with MCI or mild ADRD who will also participate in the study

Exclusion

lives in an assisted living facility or nursing home
has moderate to severe ADRD as measured by the Quick Dementia Rating System
has a life expectancy of less than 6 months.
has MCI or dementia
has a severe mental illness or substance abuse
has a life expectancy of less than 6 months.

What this trial measures

  • Reduction in BPSD as measured by the Neuropsychiatric Inventory (NPI) total scoreBaseline and Month 3

    Caregivers assess multiple (12) behavior domains for the patient. For each behavior that is present, behavior frequency and severity are rated. Frequency is rated on a 4 point scale, with 1 indicating rare behavior and 4 indicating very frequent behavior. Severity is rated on a 3 point scale, with 1 indicating mild behavior and 3 indicating severe behavior. The product of frequency multiplied by severity equals the total domain score for each behavior. Total domain scores are then summed to obtain the NPI total score. NPI total scores can range from 0 to 144, with higher scores indicating more frequent and severe behaviors overall.

  • Rate of all-cause hospitalizations and emergency visits during the study periodBaseline through study completion, approximately 3 months

    These data will be collected and used to assess whether a reduction in BPSD may lead to fewer crisis events requiring acute medical care.