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DEFINE-IRD: Understanding Vision and Navigation in Inherited Retinal Diseases

This observational study, called DEFINE-IRD, is looking at how well different vision tests work for people with moderate to profound vision loss from inherited retinal diseases. These conditions include Retinitis Pigmentosa, Stargardt Macular Dystrophy, Stargardt Disease, Geographic Atrophy from Age-related Macular Degeneration, and X-linked Retinoschisis. The study aims to see if these tests can accurately measure changes in your peripheral (side) vision and how well you can navigate and find your way around in the real world. Researchers want to enroll about 25 participants who are at least 18 years old, have a confirmed diagnosis of one of these conditions affecting both eyes, and have vision between 20/200 and hand motion (HM) in at least one eye. The study is currently unclear on its recruitment status.

Study design
This is an observational study, meaning no new treatments are given. It plans to include about 25 participants.
What's involved
You would undergo a battery of visual assessments to test your vision. These assessments will be measured over a period of 3 months.
Compensation
Not stated in the trial record.
Follow-up
Your participation in the study will involve assessments over a 3-month period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07502664

Development and Evaluation of Functional Visual Field and Navigation Endpoints in Moderate to Profound Inherited Retinal Disease (DEFINE-IRD)

Recruiting
Not specifiedAges 18+Observational
Ray Therapeutics, Inc.
~25 participants
Updated 2026-03-31 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Operational feasibility of testing moderate to profound vision impaired patients with various retinal dystrophies on a battery of visual assessments
Measured over 3 months

Conditions

Retinitis Pigmentosa
Stargardt Macular Dystrophy
Stargardt Disease
Geographic Atrophy From Age-related Macular Degeneration
X-linked Retinoschisis
Retinal Dystrophies

Explore related trials

Geographic AtrophyJuvenile X-Linked RetinoschisisRetinal DystrophyRetinitis PigmentosaStargardt Macular Dystrophy

Where it's being run

1 sites across 1 states
California1

Who to contact

Reem Jaber, MS, CGC
[email protected]
949-264-3793
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Diagnosis of bilateral retinitis pigmentosa (RP) or other retinal dystrophies impacting peripheral vision as confirmed from previous eye examination records
Best-corrected visual acuity between 20/200 to HM in at least one eye.
Reasonably fluent in English or Spanish

Exclusion

Cognitive impairment, memory loss or dementia sufficient in severity to preclude informed consent or in the opinion of the investigator would prevent satisfactory completion of some or all of the testing.
Any circumstance that in the opinion of the investigator, would interfere with participation in, or compliance with the study protocol
Current pregnancy as reported by patient

What this trial measures

  • Operational feasibility of testing moderate to profound vision impaired patients with various retinal dystrophies on a battery of visual assessments3 months

    Determining how many patients in the visual range 20/200 - HM (depending upon indication) can perform specific tests of visual function with a measurable score.