Back to search results

DEEPGAIT Study: Understanding Walking Problems in Pediatric Cancer Patients

The DEEPGAIT study is looking at how walking problems affect children and teenagers (ages 5-20) who have had orthopedic surgery for bone sarcoma, soft tissue sarcoma, or steroid-induced avascular necrosis (a condition where bone tissue dies due to lack of blood supply). This observational study uses advanced tools like 3D gait assessment (measuring how you walk), wearable sensors, and functional tests to understand how these issues change over time. Researchers will compare these patients' walking patterns to healthy children to see the differences. The main goal is to measure walking speed one year after surgery and find ways to improve long-term movement and quality of life for these young people. This study is not testing a new treatment, but rather gathering detailed information to help improve future care.

Study design
This is an observational study with a planned enrollment of 300 participants. It compares walking patterns in pediatric cancer patients to healthy children of the same age and sex.
What's involved
Participants will undergo lab-based walking tests, functional assessments, and complete questionnaires. They will also wear sensors for 7 days at home and complete a daily 5-minute walking task.
Compensation
Not stated in the trial record.
Follow-up
Case participants will be followed for 1, 2, and 5 years post-surgery. Control participants will have one assessment on Day 1.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07502885

Deep Phenotyping Gait Deficits in Orthopedic Manifestations of Pediatric Cancer Patients

Recruiting
Not specifiedAges 5–20Observational
St. Jude Children's Research Hospital
~300 participants
Updated 2026-06-18 on ClinicalTrials.gov
What's tested:Lab based 3D Gait AssessmentWearable Inertial Sensors (In Lab and Remote)Functional Testing & Patient Reported OutcomesRemote Wearable Sensor Assessment

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Gait velocity (meters/second)
Measured over Case participants: Baseline/study entry, 1, 2, and 5 years post-surgery. Control participants: Day 1

Conditions

Sarcoma, Bone
Sarcoma, Soft Tissue
Gait Disorder

Explore related trials

Avascular NecrosisSarcoma

Where it's being run

1 sites across 1 states
Tennessee1

Study leadership

  • Joshua Burns, PhD · PRINCIPAL_INVESTIGATOR · St. Jude Children's Research Hospital

Who to contact

Joshua Burns, PhD
[email protected]
888-226-4343
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Participant requiring orthopedic surgery due to a diagnosis of lower limb bone sarcoma, soft tissue sarcoma, or steroid-induced avascular necrosis (Appendix III) and will receive further additional treatment and/or follow-up care at St. Jude.
Participant is between the ages of ≥5 and ≤20 years old at the time of enrollment.
Participant is between the ages of ≥5 and ≤20 years old at the time of enrollment.
Participant (or their parent/legal guardian) considers themself healthy for their age.
Participant (or their parent/legal guardian) reports being able to participate in normal daily activities of life with respect to their age.

Exclusion

Individuals with pre-existing genetic/congenital disorders affecting gait will be excluded e.g., cerebral palsy.
Individuals who are unable to follow age-appropriate instructions during the gait assessment.
Inability or unwillingness of research participant or legal guardian/representative to give written informed consent.
Individuals diagnosed with radiation-induced avascular necrosis.
Individuals who are unable to follow age-appropriate instructions during the gait assessment.
Individuals who self-report health conditions affecting gait and mobility.
Individuals who have the following conditions: diabetes mellitus due to impaired circulation, sensation and strength, malignant cancers, demyelinating inflammatory and degenerative neurological conditions, pregnancy, obesity (BMI \>40 kg/m2), severe cardiac or pulmonary disease affecting performance of daily activities, history of major surgery affecting gait and mobility, infections or inflammatory arthropathies, severe mobility impairment necessitating dependence on mobility aids for all ambulation.
Individual or legal guardian/representative is unable or unwilling to give written informed consent.

What this trial measures

  • Gait velocity (meters/second)Case participants: Baseline/study entry, 1, 2, and 5 years post-surgery. Control participants: Day 1

    Descriptive statistics will be reported for case participants, both longitudinally and in comparison with controls, at baseline, 1, 2, and 5 years post-surgery. Descriptive statistics will be reported for controls at Day 1.