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Geranylgeraniol (GG) Supplementation for Muscle Health

This study is looking at how a dietary supplement called Geranylgeraniol (GG) affects muscle health. Researchers want to see if taking GG daily for 8 weeks can improve muscle strength and body composition (how much fat and muscle you have). You would be given either a placebo (olive oil), 150 mg of GG, or 300 mg of GG daily. The study is looking for healthy, physically active men and women between 30 and 60 years old with a body mass index (BMI) between 18.5 and 29.9. To see if the GG works, researchers will measure your leg press and bench press strength, and your fat-free mass (muscle mass) at the beginning and end of the 8-week study period. The study aims to enroll about 70 participants.

Study design
This is a randomized, double-blind, placebo-controlled study, meaning participants are randomly assigned to a group, and neither you nor the researchers will know which treatment you are receiving. Approximately 70 participants will be enrolled.
What's involved
You would take a daily supplement for 8 weeks and maintain your usual diet. You would also need to avoid alcohol, caffeine, and strenuous exercise for 24 hours before each test day, and attend screening, baseline, week 4, and week 8 visits for assessments including strength tests, body composition measurements, and blood draws.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 8 weeks, with final measurements taken at Week 8.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07502924

Dose-Response Impact of Geranylgeraniol (GG) Supplementation on Muscle Health

Recruiting
NAAges 30–60InterventionalBasic science
Lindenwood University
~70 participants
Updated 2026-03-31 on ClinicalTrials.gov
What's tested:Dietary Supplement - PlaceboGeranylgeraniol (150 mg)Geranylgeraniol (300 mg)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Leg Press One-Repetition Maximum (1RM)
Measured over Change from baseline (Week 0) to Week 8
+2 more outcomes measured

Conditions

Muscle Health
Muscle Strength
Body Composition

Explore related trials

Body PositionMuscle HealthMuscle Strength

Where it's being run

1 sites across 1 states
Missouri1

Study leadership

  • Chad M Kerksick, PhD · PRINCIPAL_INVESTIGATOR · Lindenwood University

Who to contact

Anthony M Hagele, MS
[email protected]
6369494785
Email the study team

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Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

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Eligibility criteria

Inclusion

Between 30 and 60 years old.
Body mass index values will range from \>18.5 and \<29.9 kg/m2
Subject agrees to maintain their existing dietary patterns throughout the study period.
Subject agrees to refrain from alcohol, caffeine, and strenuous exercise for 24 hours prior to each test day.
Is physically active, defined as at least 30 min of moderate exercise on at least 4 days a week.
Avoid consumption of pomegranate juice and avoid consumption of CoQ10, vitamin B3 and its precursors, L-carnitine, MK-4
Subject is willing and able to comply with the study protocol.
Subject has given voluntary, written, informed consent to participate in the study.

Exclusion

BMI \<18.5 or \> 29.9 kg/m2
Positive medical history and/or is currently being treated for some form of heart disease, cardiovascular disease, kidney disease, renal failure, or has dialysis performed on regular intervals, Type I or Type II diabetes (determined as fasting blood glucose \> 126 mg/dL), thyroid disease, liver disease or some form of clinically diagnosed hepatic impairment, immune disorder (i.e., HIV/AIDS), or neurological condition or disease.
Diagnosed with any affective disorder or other psychiatric disorder that required hospitalization in the prior year.
History of cancer (except localized skin cancer without metastases or in situ cervical cancer within 5 years prior to screening visit).
Participant has an abnormality or obstruction of the gastrointestinal tract precluding swallowing (e.g., dysphagia) and digestion (e.g., known intestinal malabsorption, celiac disease, inflammatory bowel disease, chronic pancreatitis, steatorrhea)
Genetic musculoskeletal and neurologic disorder known to affect skeletal muscle metabolism
Has donated blood in past 60 days
Diagnosed with or being treated for any endocrinological disorder and/or taking hormone boosting supplements (e.g. herbs) or hormone replacement therapy (prescribed/doctor ordered or not)
Had CoQ10 supplement in past 30 days. Had steroid medication one month before starting the study
Currently prescribed for the first time a statin drugs (i.e., Lipitor, Livalo, Crestor, Zocor, etc.) and/or a hypertension medication (i.e., Beta-blockers, ACE Inhibitors, Alpha blockers, - Vasodilators, etc.) within the past 6 months or has had their dosage or medication changed within the past 6 months
Current smoker (average of \> 1 pack per week within the past 3 months) or has quit within the past six months. This includes all forms of nicotine
Intake of any drugs (prescribed or over the counter) or dietary supplements that are known or are purported to impact energy expenditure or weight loss (caffeine doses \<300 mg/day is permissible)
Women with a history of hormone-related conditions such as endometriosis, fibroids, polycystic ovary syndrome
Women who are pregnant, planning to become pregnant, or lactating currently or within the past six months
Have a known sensitivity or allergy to any of the study products
History of alcohol or substance abuse in the 12 months prior to screening
Receipt or use of an investigational product in another research study within 30 days of beginning the study protocol
Has participated in other clinical trials focused on physical and muscle performance within the last year
They plan major changes in lifestyle (i.e., diet, dieting, exercise level, travel, etc.) during the study
Individuals who regularly compete as part of sanctioned athletic activities or those individuals who regularly train more than 360 minutes of exercise per week
Recent history (\<3 months) of exercise training or weight loss (\> 5%)
Any condition or abnormality that, in the opinion of the investigator, would compromise the safety of the participant or the quality of the study data

What this trial measures

  • Leg Press One-Repetition Maximum (1RM)Change from baseline (Week 0) to Week 8

    Maximal lower-body strength will be assessed as leg press one-repetition maximum (1RM), defined as the greatest load that can be lifted for one complete repetition using proper technique.

  • Bench Press One-Repetition Maximum (1RM)Change from baseline (Week 0) to Week 8

    Maximal upper-body strength will be assessed as bench press one-repetition maximum (1RM), defined as the greatest load that can be lifted for one complete repetition using proper technique.

  • Fat-Free MassChange from baseline (Week 0) to Week 8

    Fat-free mass will be assessed using a four-compartment body composition model derived from dual-energy X-ray absorptiometry (DEXA) and bioelectrical impedance spectroscopy (BIS).