Concurrent Chemo/Endocrine Therapy for HER2+ Breast Cancer

This research study is looking at a new way to treat hormone receptor positive (HR+), HER2 positive (HER2+) breast cancer. Normally, patients receive chemotherapy and HER2-targeted therapy first, followed by endocrine therapy and surgery. This study will test if giving endocrine therapy at the same time as chemotherapy and HER2-targeted therapy, called "Concurrent endocrine therapy with the chemotherapy and HER2 directed therapy," improves how well patients respond to treatment before surgery. You may be able to join if you are an adult over 18 with newly diagnosed, previously untreated HR+, HER2+ breast cancer. The study aims to enroll 30 participants and will measure the complete response rate (pCR Rates) at 21 months to see if the new approach is successful. The current recruitment status is unclear.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 30 participants, but the phase of the study is not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, pCR Rates, will be measured at 21 months after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07506876

Concurrent Neoadjuvant Chemo/Endocrine Therapy in HER2+ Breast Cancer

Recruiting
PHASE2Ages 18+InterventionalTreatment
Legacy Health System
~30 participants
Updated 2026-05-01 on ClinicalTrials.gov
What's tested:Concurrent endocrine therapy with the chemotherapy and HER2 directed therapy

At a glance

Recruiting sites
4 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
pCR Rates
Measured over 21 months
Breast Cancer - Infiltrating Ductal Carcinoma
HER-2 Positive Breast Cancer
4 sites across 2 states
Oregon3
Washington1
Legacy Oncology Clinical Research
Email the study team

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  • pCR Rates21 months

    To estimate the rates of pCR in patients receiving neoadjuvant chemotherapy combined with HER2 directed therapy and concurrent endocrine therapy, compared with matched historical controls who received neoadjuvant chemotherapy and HER2 directed therapy alone, stratified by molecularly determined Luminal versus HER2 enriched subtypes