High Resolution Pharyngeal Manometry (HRPM) Biofeedback Study
This study is looking at how visual feedback from High Resolution Pharyngeal Manometry (HRPM) can help improve swallowing. HRPM is a diagnostic tool that uses a small tube with sensors to measure pressures and timing in your throat during swallowing. Researchers want to see if seeing these measurements in real-time (visual biofeedback) helps healthy adults aged 18-40 perform swallowing exercises better. They will measure changes in how strongly your throat muscles contract and how long a part of your throat called the pharyngoesophageal segment (PES) opens, both with and without this visual feedback. The study also aims to understand participants' feelings about using HRPM and visual biofeedback. Currently, the recruitment status is unclear, and the study plans to enroll 50 healthy individuals.
- Study design
- This is an interventional study planning to enroll 50 healthy participants. It is not specified if it is randomized or blinded.
- What's involved
- You would perform various swallowing maneuvers, such as regular-effort, effortful, Mendelsohn, and Masako/tongue hold swallows, both with and without visual biofeedback from the HRPM device. These measurements will be taken at baseline and for up to 2 minutes with HRPM.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for up to 2 minutes during the HRPM measurements.
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High Resolution Pharyngeal Manometry (HRPM) Biofeedback
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Sonja Molfenter · PRINCIPAL_INVESTIGATOR · NYU Langone Health
Who to contact
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What this trial measures
- Change in pharyngeal contractile integral (PhCI) (mmHg) with and without visual biofeedback via HRPMBaseline (without HRPM), with HRPM (up to 2 minutes)
Pharyngeal contractile integral, a product of mean pharyngeal contractile amplitude, length, and duration. Low PhCI (\< 100-150 mmHg·s·cm): Indicates hypo-contractility or weakness while High PhCI (\> 200-300+ mmHg·s·cm): Represents stronger contraction strength
- Change in pharyngoesophageal Segment (PES) opening duration (ms) with and without visual biofeedback via HRPMBaseline (without HRPM), with HRPM (up to 2 minutes)
Measures the duration of Upper Esophageal Sphincter (UES) opening in milliseconds. Short Duration (\<300ms) correlates with upper esophageal sphincter dysfunction, reduced laryngeal elevation, and poor pharyngeal contraction.
- Change in PES pressure with visual biofeedback via HRPM with and without visual biofeedback via HRPMBaseline (without HRPM), with HRPM (up to 2 minutes)