NCT07508241
A Study to Learn About the Effect of Study Medicine Called PF-08653944 on How Quickly the Stomach Empties Its Content in Healthy Adults With Overweight or Obesity
Active, Not Recruiting
PHASE1Ages 18+InterventionalBasic sciencePfizer
~22 participants
Updated 2026-07-09 on ClinicalTrials.gov
What's tested:PF-08653944Acetaminophen
At a glance
Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Acetaminophen Pharmacokinetic (PK) Parameters: Maximum observed plasma concentration (Cmax)
Measured over Day 1 pre-dose through approximately 11 Weeks after last dose of study intervention.
+2 more outcomes measured
Conditions
Where it's being run
1 sites across 1 statesConnecticut1
Study leadership
- Pfizer CT.gov Call Center · STUDY_DIRECTOR · Pfizer
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
Do you actually qualify for this trial?
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Eligibility criteria
Inclusion
Adults ≥18 years at screening, male or female, generally healthy as determined by medical history, physical examination, laboratory tests, and ECG.
Body mass index (BMI) 27-45 kg/m² and body weight \>50 kg (110 lb).
Participants with overweight or obesity
Exclusion
History or presence of clinically significant medical conditions, including but not limited to:
Cardiovascular, hepatic, renal, pulmonary, endocrine, hematologic, neurologic, gastrointestinal (including pancreatitis or gallbladder disease), or significant psychiatric disorders.
Any form of diabetes, HbA1c ≥6.5%, or fasting plasma glucose ≥126 mg/dL.
Prior exposure to a GLP-1 receptor agonist within 90 days before first dose, or prior participation in a study with PF-08653944.
What this trial measures
- Acetaminophen Pharmacokinetic (PK) Parameters: Maximum observed plasma concentration (Cmax)Day 1 pre-dose through approximately 11 Weeks after last dose of study intervention.
To assess the effect of multiple SC doses of PF-08653944 on the plasma PK profile of acetaminophen, a marker for gastric emptying, in healthy adult participants with overweight or obesity.
- Acetaminophen PK parameters: Area under the plasma concentration (AUC)Day 1 pre-dose through approximately 11 Weeks after last dose of study intervention.
To assess the effect of multiple SC doses of PF-08653944 on the plasma PK profile of acetaminophen, a marker for gastric emptying, in healthy adult participants with overweight or obesity.
- Acetaminophen PK parameters: Time to Maximum concentration (Tmax)Day 1 pre-dose through approximately 11 Weeks after last dose of study intervention.