Transcranial Ultrasonic Neuromodulation Study for Healthy Volunteers
This study is testing a new technology called Transcranial Focused Ultrasound Stimulation. This device sends focused sound waves through your skull to gently change brain activity in specific areas, like those involved in seeing or hearing. Researchers want to understand how different settings of the ultrasound affect brain activity. You can join if you are a healthy adult between 21 and 55 years old and don't have any medical conditions that would prevent an MRI scan. The study will measure changes in your brain's electrical activity and how well you can detect sights and sounds. The current status of the study is unclear, and it plans to enroll 20 participants.
- Study design
- This is an interventional study with 20 healthy adult participants. It is not specified if it's randomized or blinded.
- What's involved
- You will have three visits for this study. These visits will involve receiving ultrasound stimulation, having your brain activity recorded with EEG, and undergoing MRI scans.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your visual and auditory detection thresholds will be measured again one week after stimulation.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Transcranial Ultrasonic Neuromodulation of Primary Visual Cortex and Primary Auditory Cortex in Humans
At a glance
Conditions
NCT07508722
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Massachusetts Institute of Technology - McGovern Institute for Brain Research
Cambridge, Massachusettsstudy coordinator listed
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Change in sensory-evoked cortical response measured by electroencephalographyMeasured during Visit 2 (baseline, during stimulation, immediately post-stimulation, and 15-20 minutes post-stimulation)
Change in peak-to-peak amplitude (µV) of sensory-evoked potentials recorded from scalp electroencephalography (EEG) over the targeted cortical region (visual or auditory cortex, depending on stimulation condition) during and after transcranial focused ultrasound stimulation, relative to baseline (pre-stimulation).
- Change in visual detection thresholdBaseline (Visit 1); pre-stimulation (Visit 2); immediately after stimulation (Visit 2); and 1 week after stimulation (Visit 3)
Change in visual sensitivity thresholds measured using the visual field analyzer, quantified as detection threshold before and after transcranial focused ultrasound stimulation.
- Change in auditory tone detection thresholdBaseline (Visit 1); pre-stimulation (Visit 2); immediately after stimulation (Visit 2); and 1 week after stimulation (Visit 3)
Change in auditory detection thresholds measured using commercial audiometry system (e.g., WAHTS Hearing), quantified as minimum detectable sound level (dB HL) across frequencies (250 Hz-8 kHz) before and after transcranial focused ultrasound stimulation.