This study is looking at how to make proton therapy (a type of radiation treatment that targets tumors precisely) even better for children with solid tumors like Rhabdomyosarcoma, Ewing sarcoma, Osteosarcoma, other sarcomas and carcinomas, or Hodgkin's lymphoma. During treatment, a child's body and tumor can change, which might make the original radiation plan less accurate. This study uses regular low-dose imaging (CT scans weekly or every other week, and MRI if needed) to check for these changes. If the tumor coverage drops by more than 5% or if healthy tissues get too much radiation, the treatment plan will be updated. The goal is to see how often these plans need to be adjusted and if this adaptive approach improves tumor control and reduces side effects. About 100 patients at St. Jude Children's Research Hospital will participate. The study's status is unclear.

Study design

This is a single-arm study involving about 100 pediatric patients. It is an interventional study, but the phase is not specified.

What's involved

You would receive additional CT scans, and MRI when needed, during your proton therapy, either weekly or every other week for the duration of your treatment (about 6 to 10 weeks).

Compensation

Not stated in the trial record.

Follow-up

The primary outcomes are measured during on-therapy imaging, which occurs for the duration of your treatment course (roughly 6 to 10 weeks).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.