ACT to Reduce Morbidity and Mortality in Hematopoietic Stem Cell Transplant Patients

This study is testing a behavioral intervention called ACTivate sessions for people undergoing stem cell transplants. ACTivate sessions use Acceptance and Commitment Therapy (ACT) to help you and your caregivers stick to recommendations for physical activity and nutrition, even when facing challenges like side effects. The study aims to see if these sessions can improve your physical function, measured by how far you can walk in six minutes. You may be able to join if you are between 18 and 80 years old, are planning to have an allogeneic (donor) stem cell transplant, and are willing to follow study procedures. The current status of this study is unclear, and it plans to enroll 476 participants.

Study design: This is a Phase 2, multicenter, randomized controlled trial. It will compare the ACTivate sessions to a control group.
What's involved: You would need to be available for the duration of the study and willing to comply with all study procedures and lifestyle considerations. The primary endpoint is measured at baseline and Day 30.
Compensation: Not stated in the trial record.
Follow-up: Physical function is measured at baseline and Day 30 after the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

ACT to Reduce Morbidity and Mortality in Hematopoietic Stem Cell Transplant Patients

Not Yet Recruiting

NAAges 18–80InterventionalSupportive care

Anthony Sung, MD

~476 participants

Updated 2026-04-07 on ClinicalTrials.gov

What's tested:ACTivate sessions

At a glance

Recruiting sites

0 of 2 listed sites are recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Change in Physical Function (Six Minute Walk Test Distance)

Measured over Baseline, Day 30

Conditions

Stem Cell Transplant Patients

Where it's being run

2 sites across 2 states

Kansas1

North Carolina1

Who to contact

Anthony Sung, MD

[email protected]

9135886030

Email the study team

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Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

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Eligibility criteria

Inclusion

Ability of participant to understand this study, and participant willingness to sign a written informed consent. NOTE: Remote / electronic consent via REDCap consenting allowed per IRB policy and approval.

Stated willingness to comply with all study procedures and lifestyle considerations and availability for the duration of the study

Plan to undergo allogeneic HCT in approximately 30 days

Males and/or females age 18 - 80 years

Agreement to adhere to Lifestyle Considerations throughout study duration

Access to necessary resources for participating in a technology-based intervention (i.e., computer, smartphone, internet access). NOTE: A smartphone will be provided to participants if needed.

Able to read/write English or Spanish (as we lack trained ACT interventionists in other languages)

Stated willingness to comply with all study procedures and lifestyle considerations and availability for the duration of the study

Males and/or females age 18-80 years

Agreement to adhere to Lifestyle Considerations throughout study duration

Access to necessary resources for participating in a technology-based intervention (i.e., computer, smartphone, internet access). NOTE: A smartphone will be provided to participants if needed.

Able to read/write English or Spanish (as we lack trained ACT interventionists in other languages)

Exclusion

Caregiver unwilling to enroll (as standard of care, all HCT patients are required to have a caregiver, but caregivers may decline to participate in this study which would make the patient ineligible for this study)

Diagnosed with a psychiatric illness or is in a social situation that would limit compliance with study requirements

Concurrent participation in another behavioral intervention research study.

Activity restrictions that limit one's ability to engage in intense physical activity

Patient unwilling to enroll

Diagnosed with a psychiatric illness or is in a social situation that would limit compliance with study requirements

Activity restrictions that limit one's ability to engage in intense physical activity

What this trial measures

Change in Physical Function (Six Minute Walk Test Distance)Baseline, Day 30
The change in physical function as measured by the difference in six minute walk test distance in meters from baseline to Day 30; a greater number of meters walked indicates a higher level of physical fitness.

Trialytics