Methadone for Pain After Spine Surgery

This study is looking at whether using methadone after spine surgery can help with pain control and reduce the amount of other pain medications (opioids) you need. Researchers want to see if methadone works as well as or better than the usual pain medication given after surgery. You could be eligible if you are an adult (18-120 years old) having elective spine surgery and expect to stay in the hospital afterward. The study is comparing methadone (0.2 mg/kg, up to 20 mg) to the standard opioid pain relief given during surgery. The main goal is to measure how much opioid medication is used from surgery until 72 hours (3 days) after.

Study design
This is a prospective cohort study, meaning researchers will follow participants over time. It plans to include 30 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your opioid use will be measured from surgery until 72 hours (3 days) after.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07517679

Methadone for Post-operative Spine Surgery

Recruiting
PHASE4Ages 18+InterventionalTreatment
Brandon Knopp
~30 participants
Updated 2026-07-20 on ClinicalTrials.gov
What's tested:MethadoneStandard of care

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Perioperative Opioid use in morphine equivalents (ME)
Measured over Perioperative until 72 hours postoperative
Pain, Postoperative
1 sites across 1 states
Kentucky1

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Eligibility criteria

Inclusion

Undergoing elective spine surgery (e.g., fusion, decompression)
Expected postoperative inpatient admission
Able to provide informed consent
Patients with opioid use disorder (OUD) may be included if on stable maintenance therapy

Exclusion

Use of regional or neuraxial anesthesia
Contraindication to methadone use (e.g., prolonged QTc, allergy, severe hepatic disease)
Cognitive impairment precluding consent or accurate pain scoring
  • Perioperative Opioid use in morphine equivalents (ME)Perioperative until 72 hours postoperative

    perioperative opioid use (morphine equivalents (ME): intraoperative, PACU, and 72-hour totals)