Nanozymes in Endodontics for Root Canal Infections
This study is looking at a new way to treat root canal infections (apical periodontitis) using a treatment called nanozymes. Researchers want to see if ferumoxytol (Feraheme®) activated with hydrogen peroxide (H₂O₂) works better than the standard treatment, which is sodium hypochlorite (NaOCl), at killing bacteria and helping your tooth heal. You might be able to join if you are 18 or older, need a root canal, and have a healthy medical history. The main goal is to see how much the bacterial count changes after one year between the two treatments. The current status of this study is unclear.
- Study design
- This interventional study plans to enroll 72 participants. It compares an experimental nanozyme treatment to standard root canal irrigation.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for one year to assess the change in bacterial count and long-term clinical outcomes.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Nanozymes in Endodontics
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
What this trial measures
- The change in bacterial count between the experimental group (Ferumoxytol/H2O2) and the standard of care (NaOCl) group.1 Year
By measuring reduction in bacteria colony forming units (CFU) before and after treatment for the experimental group (Ferumoxytol/H2O2) and the standard of care (NaOCl) group, then comparing the two groups. Samples 1-2 will be taken during the first root canal treatment visit. Sample 1 before cleaning or shaping the root canal. Sample 2 after cleaning and shaping of the root canal using laser or NaOCl. Sample 3 will be taken in the second visit, upon completion of final routine irrigation protocol.