Pulmonary Embolism and Right-to-Left Shunts Study
This study is looking at people who have had a pulmonary embolism (a blood clot in the lung) and also have a "right-to-left shunt" (RLS). An RLS is often caused by a patent foramen ovale (PFO), which is a small hole in the heart that didn't close after birth. Researchers want to understand if having an RLS increases the risk of having a stroke or small, undetected strokes (silent cerebral infarcts) within 90 days of a pulmonary embolism. You might be able to join if you are 18 or older, have had an acute pulmonary embolism, and can give consent. This is an observational study, meaning no specific treatments are being tested.
- Study design
- This is an observational study planning to enroll 256 participants. It is not specified if it is randomized or blinded.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 90 days to check for strokes or silent cerebral infarcts.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Pulmonary Embolism and Right-to-Left Shunts
At a glance
Conditions
NCT07519876
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Tufts Medical Center
Boston, Massachusettsstudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Combined incidence of acute ischemic stroke and silent cerebral infarct90 Days
1. Acute ischemic stroke incidence through 90 days defined as an acute focal neurological deficit presumed to be due to focal cerebral or retinal ischemia and either: a) Persisting \>24 hours b) Persisting \<24 hours but associated with a neuroanatomically relevant cerebral or retinal infarct documented with MRI or CT or direct retinal observation. 2. Silent cerebral infarct through 90 days defined as the presence of at least one new hyperintense lesion of 3 mm or greater in diameter on T2-weighted MRI between the screening MRI and the 90-day MRI in the absence of a relevant clinical event.