Aspirin Dosing in Pregnancy for Preeclampsia Risk

This study is looking at how different doses of aspirin affect pregnant people who are at high risk for preeclampsia (a serious pregnancy complication involving high blood pressure). Researchers want to understand how 81mg of aspirin taken twice a day (162mg total) affects platelets (tiny blood cells that help with clotting). You may be able to join if you are pregnant, between 18 and 50 years old, receiving prenatal care at NYU Langone Health Obstetrics and Gynecology Associates, and have a single pregnancy. You also need to be at high risk for preeclampsia based on certain clinical factors. The study will measure how well platelets clump together after you've been taking aspirin for about four weeks. This study is currently recruiting 30 participants.

Study design
This is an interventional study with a planned enrollment of 30 participants. It is a single-arm study, meaning all participants receive the same intervention.
What's involved
You would take 81mg of aspirin twice a day. Blood samples will be collected at the beginning of the study and again about 4 weeks after you start taking aspirin.
Compensation
Not stated in the trial record.
Follow-up
Platelet aggregation will be measured at baseline and 4 weeks after starting aspirin.

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NCT07525635

Aspirin Dosing in Pregnancy

Recruiting
EARLY_PHASE1Ages 18–50InterventionalPrevention
NYU Langone Health
~30 participants
Updated 2026-05-18 on ClinicalTrials.gov
What's tested:Aspirin

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Measures of platelet aggregation assessed by Light Transmission Aggregometry (LTA)
Measured over Baseline, 4 weeks after initiation of aspirin
Preeclampsia Possible
1 sites across 1 states
New York1
  • Christina A. Penfield, MD, MPH · PRINCIPAL_INVESTIGATOR · NYU Langone Health

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Eligibility criteria

Inclusion

Pregnant people prior to 17 weeks
Prenatal care at NYU Langone Health Obstetrics and Gynecology Associates
Age 18-50 years
Singleton viable gestation
Pregnant patients at high risk of preeclampsia: Patients meeting USPSTF recommendation for aspirin prophylaxis for preeclampsia based on clinical risk factors.

Exclusion

Undergoing glucose challenge test (GCT) at time of blood draw
Allergy or intolerance to aspirin
Antithrombotic or antiplatelet therapy
Anemia (hemoglobin \<10 g/dl) or thrombocytopenia (platelet count \<100,000), or thrombocytosis (platelet count \>600,000)
Known hemorrhagic diathesis
Planned delivery outside of NYU
  • Measures of platelet aggregation assessed by Light Transmission Aggregometry (LTA)Baseline, 4 weeks after initiation of aspirin