Investigating Non-Contrast CT for Pulmonary Embolism

This study is looking into whether a special type of CT scan, called a non-contrast chest CT (NCCT), can help find acute pulmonary embolism (blood clots in the lungs) without needing an injected dye. If you join, you'll have two extra, very low-dose CT scans that take less than a minute, in addition to your regular CT scan. You'll also be trained to hold your breath using a spirometer (a device to measure lung function). The study is for adults aged 21 and older who are already getting a CT scan for suspected pulmonary embolism. The main goal is to see how well the non-contrast CT can rule out pulmonary embolism, with results being checked up to two years later. The current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 750 participants. It is not specified if it is randomized or blinded.
What's involved
You will have two extra, low-dose CT scans and be trained to use a spirometer. Your total participation time is about 5 minutes, and your medical records will be reviewed for 30 to 90 days after your CT scan.
Compensation
Not stated in the trial record.
Follow-up
Your medical records will be reviewed for up to 30 to 90 days after your CT scan. The primary endpoint for ruling out PE on non-contrast CT is measured at 2 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07527117

Role of n On-contrast Chest CT (NCCT) Based CT V: Q in Patients With Acute Pulmonary Embolism (aPE)

Recruiting
NAAges 21+InterventionalDiagnostic
Massachusetts General Hospital
~750 participants
Updated 2026-09-11 on ClinicalTrials.gov
What's tested:Additional CT acquisition at low dose (1- 2 mSv)

At a glance

Recruiting sites
1 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
NPV for ruling out PE on non-contrast CT
Measured over 2 years
Pulmonary Embolism (Diagnosis)
Pulmonary Embolism Acute

NCT07527117

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Massachusetts General Hospital

    Boston, Massachusettsstudy coordinator listed

    Not yet recruiting

  • Massachusetts General Hospital/Harvard Medical School

    Boston, Massachusettsstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

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  • NPV for ruling out PE on non-contrast CT2 years

    Negative predictive value