This study is looking at whether disulfiram, an FDA-approved medicine for alcohol use disorder, can help people with rheumatoid arthritis (RA) who also have obesity. RA is a long-lasting disease that causes joint inflammation. Obesity can make RA worse. Researchers believe disulfiram might work by blocking a specific pathway (GSDMD-mediated inflammatory signaling) that causes inflammation. You would receive either disulfiram (250 mg once daily) or a placebo (an inactive pill that looks the same) for 12 weeks. The main goal is to see how safe disulfiram is and if people can tolerate it. To join, you need to be 18-75 years old, have RA with active disease, a BMI of 25 or higher, and be on stable RA medication. The study plans to enroll 20 participants, but its current status is unclear.

Study design

This is an interventional study comparing disulfiram to a placebo. It plans to enroll 20 participants.

What's involved

You would take a pill once daily for 12 weeks. You would also need to avoid alcohol during the study.

Compensation

Not stated in the trial record.

Follow-up

Safety and tolerability will be measured from the beginning of the study through Week 12.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.