Back to search results

Behavioral Program for Weight Loss Maintenance After GLP-1 and Anti-Obesity Medication Discontinuation

This study is looking for people who have lost a significant amount of weight using GLP-1 or other anti-obesity medications and have recently stopped or plan to stop taking them. The goal is to test different behavioral programs to help you maintain your weight loss. These programs include a 10-week foundational program focusing on food, exercise, and mind-based practices, potentially combined with medically tailored meals (Mom's Meals), a YMCA membership, or the SKY Meditation Program. Researchers will be looking at how many people stay in the program and how well they stick to the foundational support sessions. The study is currently recruiting 64 participants.

Study design
This is a pilot randomized factorial study involving 64 participants. It is designed to evaluate different combinations of behavioral interventions.
What's involved
You would participate in a 6-month behavioral intervention, including a 10-week foundational program. Your retention will be measured at 3 and 6 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for six months after starting the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07535892

Scalable Behavioral Program for Weight Loss Maintenance After GLP-1 and Anti-Obesity Medication Discontinuation

Not Yet Recruiting
NAAges 18+InterventionalTreatment
University of Alabama at Birmingham
~64 participants
Updated 2026-06-26 on ClinicalTrials.gov
What's tested:Weight Loss Maintenance Program (Foundational)Mom's MealsYMCA MembershipSKY Meditation Program

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percentage of participants retention
Measured over 3 months, 6 months,
+1 more outcome measured

Conditions

Weight Loss
GLP - 1
Weight Loss Maintenance
Obesity & Overweight

Explore related trials

ObesityOverweight

Where it's being run

1 sites across 1 states
Alabama1

Study leadership

  • Holly Wyatt, MD · PRINCIPAL_INVESTIGATOR · University of Alabama at Birmingham

Who to contact

Holly Wyatt, MD
[email protected]
303-378-6720
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Age 18 years or older
Loss of ≥15% of initial body weight using anti-obesity medication
Discontinued anti-obesity medication within the past 4 weeks or planning to discontinue prior to randomization
≤3 kg weight regain within the past 3 months
Willing and able to participate in a 6-month behavioral intervention, including a 10-week foundational program
Willing to complete study assessments at baseline, 3 months, and 6 months, including required in-person visits
Medical clearance for participation in moderate physical activity, dietary modification, and mind-based practices
Access to reliable internet for participation in virtual sessions and remote data collection
English fluency sufficient to complete study procedures
Able to provide informed consent

Exclusion

Medical conditions that would preclude safe participation in physical activity, dietary changes, or mind-based practices (e.g., unstable cardiovascular disease, uncontrolled hypertension, severe orthopedic limitations, or seizure disorders not medically managed)
Active psychiatric conditions that would interfere with participation or safety (e.g., untreated major depression, active substance use disorder, or psychosis)
Pregnancy, breastfeeding, or plans to become pregnant during the study period
Current participation in another structured weight loss or weight maintenance program
Continued use of anti-obesity medication after randomization
Plans to initiate medications or treatments that may significantly affect body weight during the study period
Inability to attend required study visits or participate in virtual sessions and remote data collection
Any condition that, in the opinion of the investigators, would compromise participant safety or study integrity

What this trial measures

  • Percentage of participants retention3 months, 6 months,

    Retention will be calculated as the proportion of randomized participants completing the 3- and 6-month follow-up assessments. For the proposed study, retention rates ≥80% over the 6-month intervention period would indicate the study is feasible as-is. If retention is \<80%, we will consider modifications to the study design and dedication of greater resources towards improving retention in the full-scale factorial trial.

  • Percentage of participants that adhered to the 10-week foundational support sessions10 weeks

    Adherence to the 10-week foundational support sessions will be measured as the percentage of attended sessions relative to scheduled sessions. For the proposed study, the feasibility benchmark for adherence was set at ≥80% attendance. If adherence is \<80%, we will consider modifications to the study design and dedication of greater resources towards improving adherence in the full-scale factorial trial. The other measures of adherence will be evaluated with descriptive statistics. Completion rates of weekly logs for food intake, physical activity, and mind-based practices will be documented and tracked in REDCap. Additionally, daily usage of Garmin scales and fitness trackers will be monitored, with rates of adherence assessed as the percentage of days that participants engage with these devices.