Ceftriaxone Dosage for Non-Critical Community-Acquired Pneumonia

This study is looking at the best dose of Ceftriaxone, an antibiotic, for people hospitalized with community-acquired pneumonia (CAP) who are not in the intensive care unit. Researchers want to see if 1 gram of Ceftriaxone daily is as effective as 2 grams daily, but with fewer side effects. You might be able to join if you are 18 or older, have CAP, and are prescribed Ceftriaxone in the emergency department or within 72 hours of hospital admission. The main goal is to see if people achieve a clinical cure, meaning their pneumonia gets better, 120 days after starting the study. The current status of this study is unclear.

Study design
This is a pragmatic trial where 430 participants will be randomly assigned to receive either 1 gram or 2 grams of Ceftriaxone daily. There will be no direct patient contact.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be assessed for clinical cure 120 days after enrollment.

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NCT07537413

Ceftriaxone Dosage for Non-Critical Community-Acquired Pneumonia

Not Yet Recruiting
PHASE4Ages 18+InterventionalTreatment
University of Maryland, Baltimore
~430 participants
Updated 2026-04-17 on ClinicalTrials.gov
What's tested:Ceftriaxone 1 gram dailyCeftriaxone 2 grams daily

At a glance

Recruiting sites
0 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Clinical cure
Measured over The outcome will be assessed 120 days after enrollment
Community Acquired Pneumonia (CAP)
2 sites across 1 states
Maryland2

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Evaluated in the emergency department or within 72 hours of hospitalization
Prescribed Ceftriaxone for community-acquired pneumonia

Exclusion

Planned or present admission to an intensive care unit
Respiratory failure requiring mechanical ventilation, non-invasive ventilation such as bilevel positive airway pressure, or high flow nasal cannula
  • Clinical cureThe outcome will be assessed 120 days after enrollment

    Defined by discharge from the hospital or antibiotic treatment for \< 8 days without any of the following: requirement for antibiotic escalation, admission to an intensive care unit, mechanical or noninvasive ventilation, readmission within 30 days, or mortality within 30 days