Adolescent PTSD Study: Understanding Stress Responses

This study is looking for adolescents aged 14-18 who have experienced trauma and have symptoms of Posttraumatic Stress Disorder (PTSD). We want to understand how young people with trauma-related symptoms react to stress and strong emotions. Participants will engage in tasks that involve responding to threats, managing emotions, and repeatedly imagining a stressful event using a technique called "script-driven imagery." We will measure anxiety levels and physical responses like heart rate and muscle activity (Corrugator Supercilii Electromyography or EMG) to see if the repeated imaginal exposure changes these responses over time. We also want to see if how you react to threats and manage emotions at the beginning of the study affects how you respond to the imaginal exposure. A caregiver must be willing to participate with you.

Study design
This interventional study plans to enroll 180 participants aged 14-18. It is not specified if the study is randomized or blinded.
What's involved
You would participate in experimental tasks, including repeated script-driven imagery tasks, at baseline and 1 week later. Your caregiver would also need to participate.
Compensation
Not stated in the trial record.
Follow-up
Your anxiety and physiological responses will be measured at baseline and 1 week after baseline.

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NCT07537764

Predictors & Mechanisms of Adolescent PTSD

Not Yet Recruiting
EARLY_PHASE1Ages 14–18InterventionalBasic science
Medical University of South Carolina
~180 participants
Updated 2026-05-08 on ClinicalTrials.gov
What's tested:Repeated imaginal exposure: Script Driven Imagery (SDI) task

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
State Anxiety (State and Trait Anxiety Inventory for Children - State Scale)
Measured over Baseline (Visit 1, prior to first script-driven imagery task) and 1 week after baseline (Visit 2, following repeated imaginal exposure)
+4 more outcomes measured
Posttraumatic Stress Disorder (PTSD)
Trauma Exposure
1 sites across 1 states
South Carolina1

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  • State Anxiety (State and Trait Anxiety Inventory for Children - State Scale)Baseline (Visit 1, prior to first script-driven imagery task) and 1 week after baseline (Visit 2, following repeated imaginal exposure)
  • Corrugator Supercilii Electromyography (EMG) ReactivityDuring script-driven imagery tasks at baseline (Visit 1) and 1 week after baseline (Visit 2)
  • Heart Rate Reactivity During Script-Driven ImageryDuring script-driven imagery tasks at baseline (Visit 1) and 1 week after baseline (Visit 2)
  • Skin Conductance Reactivity During Script-Driven ImageryDuring script-driven imagery tasks at baseline (Visit 1) and 1 week after baseline (Visit 2)
  • Posttraumatic Stress Disorder Symptoms (UCLA PTSD Reaction Index for DSM-5)Baseline (Visit 1) and 1 month after baseline (Visit 3)