Suzetrigine for Pain After Total Knee Arthroplasty

This study is looking at how well Suzetrigine helps manage pain after total knee arthroplasty (TKA), also known as total knee replacement surgery. Researchers want to see if taking Suzetrigine can reduce the need for opioid pain medications after surgery. You might be able to join if you are between 18 and 80 years old, have a body mass index (BMI) between 18 and 40, and are scheduled for your first total knee replacement on one knee. The main goal is to see how many participants can stay opioid-free for up to 14 days after surgery. The study is currently recruiting about 60 participants, but its overall status is unclear.

Study design
This is an interventional study involving about 60 participants. Participants will receive either Suzetrigine tablets or a matching placebo.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome is measured from Day 1 up to Day 14 after surgery.

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NCT07538570

Evaluation of Pain Treatment After Total Knee Arthroplasty

Recruiting
PHASE4Ages 18–80InterventionalTreatment
Vertex Pharmaceuticals Incorporated
~60 participants
Updated 2026-08-18 on ClinicalTrials.gov
What's tested:SuzetriginePlacebo

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Total Opioid Usage
Measured over 24 hours to 168 hours after the first dose of study drug
Pain
2 sites across 1 states
Texas2

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Eligibility criteria

Inclusion

Body mass index (BMI) of greater than or equal to (≥) 18.0 to less than or equal to (≤) 40.0 kilogram per meter square (kg/m\^2)
Scheduled to undergo an elective primary unilateral TKA surgery
  • Total Opioid Usage24 hours to 168 hours after the first dose of study drug