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Observing Breathing Patterns in Premature Infants Before and After Extubation

This study is looking at how premature infants (born at 32 weeks gestation or earlier) breathe before and after their breathing tube is removed (extubation). Researchers will observe the baby's "work of breathing" (how hard or easy they breathe) using soft, elastic bands placed on their chest and abdomen. These bands measure how well the chest and abdomen move together during breathing. The goal is to see if these measurements can better predict which babies are ready to have their breathing tube removed successfully, compared to current methods. This study is for premature infants who are currently on a breathing tube and whose medical team is considering removing it. The study aims to enroll 30 infants.

Study design
This is an observational study involving 30 premature infants. It will compare breathing patterns before and after the breathing tube is removed.
What's involved
Soft elastic bands will be placed on your baby's chest and abdomen to measure their breathing. These measurements will be taken before, during, and after routine breathing tests, and if the breathing tube is removed.
Compensation
Not stated in the trial record.
Follow-up
Work of breathing will be measured before and after extubation, with a specific measurement taken at 25 minutes after extubation.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07542301

Breathing Patterns in Infants Before and After Extubation

Recruiting
Not specifiedAges 0–6Observational
Christiana Care Health Services
~30 participants
Updated 2026-04-21 on ClinicalTrials.gov
What's tested:Observation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Work of breathing before and after extubation
Measured over 25 minutes

Conditions

Respiratory Distress Syndrome (RDS)
PreTerm Neonate

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NCT07542301

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • ChristianaCare Health Services, Inc.

    Newark, Delawarestudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Kelley Z Kovatis, MD · PRINCIPAL_INVESTIGATOR · Christiana Care Health Services, Inc

Who to contact

Kelley Z. Kovatis, MD
[email protected]
302-301-2410
Email the study team

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Eligibility criteria

Inclusion

premature infants (born at ≤32 weeks gestation) who are intubated.
medical team is evaluating the baby for extubation readiness

Exclusion

Infants with skeletal, neuromuscular, or abdominal surgical disorders that affect the accuracy of RIP measurements will be excluded.

What this trial measures

  • Work of breathing before and after extubation25 minutes

    The primary objective of this study is to compare work of breathing indices before and after extubation in intubated premature infants admitted to the Christiana Care Neonatal Intensive Care Unit. We will observe work of breathing for 5-10 minutes before the infant is extubated and 5-10 minutes after the infant is extubated.