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Suzetrigine for Pain After Total Knee Replacement Surgery

This study is testing a new pain medication called Suzetrigine for people having total knee replacement surgery. Suzetrigine works by blocking pain signals in your nerves. Researchers want to see if adding Suzetrigine to standard pain care can reduce the amount of opioid pain medication you need after surgery and lower your pain levels. You can join if you are between 18 and 85 years old and scheduled for total knee replacement surgery. Participants will be randomly assigned to receive either Suzetrigine or a placebo (an inactive substance). The main goal is to measure how much opioid medication you use in the first five days after surgery.

Study design
This is a randomized study involving 235 participants. You will be randomly assigned to receive either Suzetrigine or a placebo.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Opioid consumption will be measured for 5 days after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07548385

Suzetrigine for Treatment and Reduction of Intense Discomfort After knEe Replacement PAIN

Recruiting
PHASE3Ages 18–85InterventionalTreatment
Icahn School of Medicine at Mount Sinai
~235 participants
Updated 2026-04-23 on ClinicalTrials.gov
What's tested:SuzetriginePlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Opioid Consumption
Measured over 5 days

Conditions

Total Knee Replacement Surgery
Post-operative Pain

Explore related trials

Post-Operative PainTotal Knee Replacement Surgery

Where it's being run

1 sites across 1 states
New York1

Study leadership

  • Michael Lazar, MD · PRINCIPAL_INVESTIGATOR · Icahn School of Medicine at Mount Sinai

Who to contact

Michael Lazar, MD
[email protected]
212-523-2500
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Adults 18-85 years old
Scheduled to undergo total knee replacement surgery
All genders

Exclusion

American Society of Anesthesiology Physical Classification (ASA) Class V
Urgent or emergent surgery
Contraindications to administration of Suzetrigine:
Patients who take moderate-to-severe CYP3A inhibitors (such as Ritonavir, Voriconazole, and Clarithromycin)
Patients who take moderate-to-severe CYP3A inducers (such as Phenytoin, Carbamazapine, and Rifabutin)
Patients with moderate to severe hepatic impairment
History of substance use disorder or chronic opioid use or alcohol abuse
Reoperation
Patient refusal or inability to consent
Pregnancy

What this trial measures

  • Opioid Consumption5 days

    Total amount of opioid consumption required post-operatively.