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Observational Study of Remote Voice Analysis for ME/CFS

This study is looking at how a remote voice analysis tool can help diagnose and monitor Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). If you have ME/CFS, confirmed by a specialist, and can use a smartphone or tablet, you might be able to join. The study will test if the Mayo Speech Test (Voice Signatures) is a good way to screen for and keep track of ME/CFS over 12 weeks. The study plans to enroll 40 participants, but its current status is unclear.

Study design
This is an observational study, meaning participants will be monitored without receiving a specific treatment. It plans to enroll 40 participants.
What's involved
You will create 5-10 minute voice recordings every two weeks for a total of 12 weeks using a mobile app and a wearable armband.
Compensation
Not stated in the trial record.
Follow-up
The primary goals of the study are measured at 12 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07551999

A Study Of Remote Voice Analysis Tool For Diagnosing And Monitoring ME/CFS

Recruiting
Not specifiedAges 18+Observational
Mayo Clinic
~40 participants
Updated 2026-05-27 on ClinicalTrials.gov
What's tested:Voice Recording

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Feasibility of Mayo Speech Test (Voice Signatures) for Screening of ME/CFS
Measured over 12 weeks
+1 more outcome measured

Conditions

Encephalomyelitis
Chronic Fatigue Syndrome

Explore related trials

Chronic Fatigue Syndrome

Where it's being run

1 sites across 1 states
Minnesota1

Study leadership

  • Stephanie L. Grach, MD, MS · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Katie Cruz
[email protected]
507-284-5404
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) verified by an ME/CFS specialist.
Ability to complete study questionnaires and provide voice samples using a smartphone application.
Consistent access to a smartphone or tablet with iOS or Android operating systems, or a laptop.

Exclusion

No diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); "Chronic Fatigue Syndrome" not verified by an ME/CFS specialist.
Lack of consistent access to a smartphone or tablet with iOS or Android operating systems, or laptop.
Known dementia or other neurodegenerative disorder prominently affecting cognition or speech patterns. outside of ME/CFS
Known history of voice disorder either primary or secondary to neuromuscular or other pathology outside of ME/CFS
Known clinically significant heart failure or greater than moderate pulmonary hypertension.

What this trial measures

  • Feasibility of Mayo Speech Test (Voice Signatures) for Screening of ME/CFS12 weeks

    Speech data will be analyzed for voice signatures that can be differentiated from people with ME/CFS and those without ME/CFS. data will be analyzed for voice signatures that can be differentiated from people with ME/CFS and those without ME/CFS.

  • Feasibility of Mayo Speech Test (Voice Signatures) for Monitoring of ME/CFS12 weeks

    Speech data will be analyzed alongside wearable data to assess feasibility of Mayo Speech Test for ME/CFS disease monitoring.