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SeeMe: Detecting Voluntary Behavior in Brain Injury

This study is testing a new tool called SeeMe, which uses automated facial tracking to detect very small movements in people with severe traumatic brain injury (TBI). Sometimes, standard tests miss these tiny movements, making it seem like a patient isn't responding when they actually are. SeeMe uses special computer vision to track facial pores and hand movements with high precision. The goal is to see if SeeMe can detect when a patient is following commands earlier than current methods, which could help ensure patients get the right care. You might be able to join if you are an adult (22-85 years old) with a severe TBI and meet other health criteria.

Study design
This is an interventional study planning to enroll 80 participants. It compares how quickly SeeMe detects command-following against standard clinical assessments.
What's involved
Participants will receive the SeeMe Multimodal Auditory Command Protocol, which involves listening to specific commands. This will occur from day 1 until hospital discharge, typically within 45 days.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome is measured from day 1 until hospital discharge, typically within 45 days.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07560631

SeeMe: Using Automated Facial Tracking to Detect Voluntary Behavior in Brain Injury

Recruiting
NAAges 22–85InterventionalDiagnostic
Stony Brook University
~80 participants
Updated 2026-05-05 on ClinicalTrials.gov
What's tested:SeeMe Multimodal Auditory Command Protocol

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Lead Time to Detection of Command-Following by SeeMe Compared With Blinded CRS-R Assessment
Measured over From Day 1 until hospital discharge, typically within 45 days.

Conditions

Traumatic Brain Injury (TBI) Patients
Severe Traumatic Brain Injury

Explore related trials

ComaConsciousness DisordersTraumatic Encephalopathy

NCT07560631

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Stony Brook University Hospital

    Stony Brook, New Yorkstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Sima Mofakham, PhD
[email protected]
631-444-1278
Email the study team

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Eligibility criteria

Inclusion

Adults (22+) with a history of acute traumatic brain injury
Documented loss of consciousness with a Glasgow Coma Scale (GCS) score less than or equal to 8 upon hospitalization
Clinically stable as determined by the primary neurosurgery or ICU team
Intact auditory pathways as confirmed by BAERs
Family consent for study participation
Adults 22+ with no history of neurological or psychiatric disorders
Normal baseline neurological examination
Intact auditory pathways
Ability to provide informed consent
Ability to follow simple auditory commands in English
Adults (22+) undergoing elective spine surgery
Requirement of general anesthesia and pharmacological paralysis (neuromuscular blockade) as part of the standard surgical procedure
Clinically stable for study procedures as determined by the anesthesia and surgical teams.
Intact auditory pathways
Ability to provide informed pre-operative consent

Exclusion

Hearing Impairment confirmed via absence of Brainstem Auditory Evoked Responses (BAERs) that would prevent the patient from hearing the auditory commands
No legal authorized representative (LAR) available to provide informed consent for the patients in a comatose state
Any other medical condition that, in the judgment of the investigator, makes participation in the study unsafe.
Pregnant women
Any previous history of traumatic brain injury
Any neurodegenerative disease such as dementia
Hearing Impairment that would prevent the participant from hearing the auditory commands
Any previous history of severe traumatic brain injury (TBI)
Any neurodegenerative disease (e.g., dementia)
Any motor impairment (e.g., facial palsy, carpal tunnel syndrome) that would interfere with facial or hand movement tracking
Any other medical condition that, in the judgment of the investigator, makes participation in the study unsafe
Pregnant women
Hearing Impairment that would prevent the patient from hearing the auditory commands
Any previous history of severe traumatic brain injury
Any neurodegenerative disease such as dementia
Significant baseline facial or hand motor deficits prior to the administration of anesthesia
Any other medical condition that, in the judgment of the investigator, makes participation in the study unsafe
Pregnant women

What this trial measures

  • Lead Time to Detection of Command-Following by SeeMe Compared With Blinded CRS-R AssessmentFrom Day 1 until hospital discharge, typically within 45 days.

    Number of days between the first SeeMe-detected significant stimulus-evoked motor response and the first blinded Coma Recovery Scale-Revised (CRS-R) assessment demonstrating command-following. A SeeMe-positive detection is defined as a stimulus-evoked movement that meets the prespecified criteria of a Kolmogorov-Smirnov statistic \>0.1 and a pixel displacement \>400. This stimulus-evoked movement must be detected reliably (at least 3 out of 10 trials). CRS-R examiners will be blinded to SeeMe outputs.