Cardiometabolic Disease and Substrate Metabolism Study
This observational study is looking at the connection between cardiometabolic diseases, like preeclampsia (high blood pressure during pregnancy) and gestational diabetes (diabetes that develops during pregnancy), and how your body uses fats for energy (maternal lipid oxidation). Researchers want to understand if insulin resistance (when your body doesn't respond well to insulin) is related to how your body processes fats early in pregnancy. You might be able to join if you are a woman between 18 and 45 years old, have certain risk factors for preeclampsia, and are willing to take aspirin and undergo specific tests. The study aims to measure your fasting insulin, insulin resistance, and how quickly your body uses fats for energy early in your pregnancy. The current status of this study is unclear, and it plans to enroll 50 participants.
- Study design
- This is an observational study, meaning researchers will observe participants without providing specific interventions. It plans to include 50 women.
- What's involved
- You would need to agree to take aspirin and undergo a 2-hour oral glucose tolerance test (OGTT) for blood collection, surveys, indirect calorimetry (to measure metabolism), and body composition measures. These measurements would occur during a single study visit between 12-18 weeks of gestational age.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoints are measured at the beginning of a single study visit between 12-18 weeks gestational age. No further follow-up is specified.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Cardiometabolic Disease and Substrate Metabolism
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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Inclusion
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What this trial measures
- Early Pregnancy Fasting Insulin (mIU/mL)Fasting, at the beginning of a single study visit between 12-18 weeks gestational age
Early pregnancy fasting insulin level (mIU/mL) in venous blood
- Early Pregnancy Homeostatic Model Assessment for Insulin ResistanceCalculated from fasting insulin and fasting glucose collected at the start of a single study visit between 12-18 weeks gestational age
Approximates early pregnancy insulin resistance.
- Early Pregnancy Fasting Lipid Oxidation Rate (g/min)Measured at the start of a single study visit between 12-18 weeks gestational age
Early pregnancy fasting lipid oxidation rate measures whole body lipid oxidation, which is assessed using indirect calorimetry
- Late Pregnancy Fasting Insulin (mIU/mL)Fasting, at the beginning of a single study visit between 26-30 weeks gestational age
Late pregnancy fasting insulin level (mIU/mL) in venous blood
- Late Pregnancy Homeostatic Model Assessment for Insulin ResistanceCalculated from fasting insulin and fasting glucose collected at the start of a single study visit between 26-30 weeks gestational age
Approximates late pregnancy insulin resistance.
- Late Pregnancy Fasting Lipid Oxidation Rate (g/min)Measured at the start of a single study visit between 26-30 weeks gestational age
Fasting late pregnancy lipid oxidation rate measures whole body lipid oxidation, which is assessed using indirect calorimetry