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rTMS for Motor Function in Cerebral Palsy

This study is looking at how repetitive transcranial magnetic stimulation (rTMS) might help improve movement in children and young adults with cerebral palsy (CP). rTMS uses gentle magnetic pulses to stimulate brain cells. Researchers will use rTMS and measure brain activity with high-density EEG (HD-EEG), a safe way to record the brain's electrical signals. The goal is to see if rTMS can help the brain reorganize itself (meta-plasticity) to improve motor skills. You might be able to join if you are 6 to 20 years old, have a confirmed diagnosis of CP, and are classified as high-functioning (GMFCS Level I, II, or III). The study aims to enroll 60 participants and will measure changes in brain responses (TMS-evoked potentials) after 4 weeks of treatment and at a 1-month follow-up.

Study design
This is an interventional study planning to enroll 60 participants. It is not specified if it is randomized or blinded.
What's involved
You would undergo an MRI scan, have HD-EEG recordings, and receive rTMS treatments. The study measures changes within 4 weeks and at a 1-month follow-up.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed up at 1-month after the sham/real rTMS intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07567053

Repetitive Transcranial Magnetic Stimulation on Motor Function and Meta-Plasticity in Cerebral Palsy: TMS-EEG Study

Not Yet Recruiting
NAAges 6–20InterventionalTreatment
Cook Children's Health Care System
~60 participants
Updated 2026-05-14 on ClinicalTrials.gov
What's tested:MRIHD-EEG RecordingrTMS

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change on TMS-evoked potentials (TEPs)
Measured over Within the end of 4 weeks and 1-month follow-up of sham/real rTMS

Conditions

Cerebral Palsy
Typically Developing Children

Explore related trials

Cerebral PalsyTypically Developing Children

Where it's being run

1 sites across 1 states
Texas1

Study leadership

  • Christos Papadelis, PhD · PRINCIPAL_INVESTIGATOR · Cook Children's Health Care System

Who to contact

Christos Papadelis, PhD
[email protected]
682-305-3236
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Aged 6 - 20 years,
A confirmed diagnosis of CP by a specialized professional (pediatric neurologist, PM\&R physician, neonatal developmental specialist, or neonatologist) is a prerequisite for participation,
Classified as high functioning (Level I, II, or III) according to the Gross Motor Function Classification System (GMFCS),
Age-appropriate ability to understand and comply with study procedure throughout the entire duration of the study,
Preserved vision and hearing (with or without correction).
Aged 6 - 20 years
Age-appropriate ability to understand and comply with study procedure throughout the entire duration of the study,
Preserved vision and hearing (with or without correction).

Exclusion

Syndromic or genetic brain-related associations,
History of major trauma or brain surgery,
Inability to remain still,
History of Epilepsy,
Severe coexisting sickness or illness unrelated to CP or unstable medical conditions such as pneumonia,
Modified Ashworth Scale: Shoulder, elbow, and wrist scores more than 3,
Limb contractures caused by any other injury except CP,
Severe movement disorders that prevent intentional limb movements, such as choreoathetosis, or ballismus,
Contraindications for rTMS include non-removable metallic objects close to a coil and implanted electronic devices, such as cochlear implants and pacemakers.
Syndromic or genetic brain-related associations,
History of major trauma or brain surgery,
Inability to remain still,
History of Epilepsy,
Severe coexisting sickness or illness unrelated to CP or unstable medical conditions such as pneumonia,
Limb contractures caused by injury,
Severe movement disorders that prevent intentional limb movements, such as choreoathetosis, or ballismus,
Contraindications for rTMS include non-removable metallic objects close to a coil and implanted electronic devices, such as cochlear implants and pacemakers.

What this trial measures

  • Change on TMS-evoked potentials (TEPs)Within the end of 4 weeks and 1-month follow-up of sham/real rTMS

    TEPs refer to the electrical responses in the brain elicited by rTMS. This technique involves applying magnetic pulses to specific brain areas, which induce electrical activity that can be recorded using EEG.