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Improving Comfort During Cesarean Delivery Spinal Anesthesia

This study is looking at ways to make spinal anesthesia for cesarean delivery more comfortable for patients. Researchers are testing if adding either dexmedetomidine (4 mcg) or clonidine (30 mcg) to standard spinal anesthesia can reduce sensations like pulling or pressure during surgery. These medications might also make the anesthesia last longer and lessen pain after the delivery. You may be able to join if you are an adult pregnant woman having a cesarean delivery with spinal anesthesia. The main goal is to see how well these additions improve comfort during the surgery itself. This study plans to enroll 150 participants.

Study design
This interventional study plans to enroll 150 women. It is comparing the effects of adding either clonidine or dexmedetomidine to spinal anesthesia.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, incidence of intraoperative discomfort, is measured during cesarean surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07567495

Adding Dexmedetomidine or Clonidine to Spinal Anesthesia for Cesarean Delivery

Not Yet Recruiting
PHASE4Ages 18+InterventionalTreatment
Columbia University
~150 participants
Updated 2026-05-05 on ClinicalTrials.gov
What's tested:ClonidineDexmedetomidine

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incidence of intraoperative discomfort
Measured over during cesarean surgery

Conditions

Cesarean Delivery
Cesarean Delivery; Neuraxial Opioids
Spinal Anesthesia for Cesarean Section
Dexmedetomidine
Clonidine
Postoperative Analgesia

Explore related trials

Deliveries by cesarean

Where it's being run

1 sites across 1 states
New York1

Study leadership

  • Ruth Landau, MD · PRINCIPAL_INVESTIGATOR · Columbia University

Who to contact

Richard M Smiley, MD, PhD
[email protected]
914-584-9531
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Pregnant women undergoing cesarean delivery with spinal anesthesia

Exclusion

Significant cardiovascular, psychiatric or respiratory disease
using opioids or with chronic pain syndrome
Multiple gestation
BMI \>40 kg/m2
Quaternary or greater cesarean
\< 37 weeks gestation
Non-English or Spanish speaking
planned vertical skin incision
planned vertical (classical) uterine incision
allergy to clonidine, dexmedetomidine or other study drug

What this trial measures

  • Incidence of intraoperative discomfortduring cesarean surgery

    The primary outcome of this study is the incidence of self-reported intraoperative discomfort, defined as pain or uncomfortable pressure, tugging, pulling feeling during cesarean delivery. At specific timepoints during cesarean delivery surgery, the patient will be asked "Do you feel uncomfortable sensations (pain, pressure, pulling, tugging)?" If the answer is "yes, " she will be asked "Do you want medication to treat it?" The timepoints specified will be: 1. Foley (urinary) catheter placement 2. Allis clamp test (testing for pain at incision site and umbilicus before starting surgery) 3. Skin incision 4. Uterine incision 5. Delivery 6. Uterine exteriorization 7. Fascial closure 8. Skin closure 9. Manual uterine compression in OR after closure 10. At any point other than the above that the patient complains of pain or uncomfortable sensations