Observational Study on Gut-Brain Connection in Parkinson's Disease

This study, called GBPDC, is looking into how the connection between your gut and brain (the gut-brain axis) might be involved in Parkinson's disease (PD). Researchers want to understand how this connection changes in people with PD, those at risk for PD, and those without the disease. They will compare different groups of people based on their PD status and severity. The study aims to collect information and samples over 24 months to better understand PD and potentially find new ways to diagnose or treat it. You might be able to join if you are between 21 and 80 years old and have a clinical diagnosis of PD, or if you are at risk for PD, or do not have PD.

Study design
This is an observational study aiming to enroll 250 participants. It will compare different groups of people based on their Parkinson's disease status.
What's involved
You would participate in scheduled visits, laboratory tests, and other study procedures. The observation period for primary endpoints is up to 24 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be observed for up to 24 months to assess GI influences on PD and co-associations components of the gut-brain axis.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07567794

GBPDC: Gut-Brain in PD Consortium Master Protocol

Recruiting
Not specifiedAges 21–80Observational
Duke University
~250 participants
Updated 2026-08-21 on ClinicalTrials.gov

At a glance

Recruiting sites
3 of 7 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
GI influences on PD
Measured over enrollment to end of observation at 24 months
+1 more outcome measured
Parkinson Disease (PD)
PARKINSON DISEASE (Disorder)
Gut Microbiome
Gut Microbiota
Prodromal Parkinsons Disease
7 sites across 6 states
Illinois2
California1
Massachusetts1
Minnesota1
New York1
South Carolina1
  • Lisa Wruck · PRINCIPAL_INVESTIGATOR · Duke Clinical Research Institute

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  • GI influences on PDenrollment to end of observation at 24 months

    Trait and State cross-sectional evaluation of GI influences on PD

  • Co-associations components of the GBAenrollment to end of observation at 24 months

    Cross-sectional co-associations components of the GBA