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Understanding Suicidal Behavior in Youth with CAMS Therapy

This study is looking at how the brain works in young people (ages 14-24) who have suicidal thoughts or have attempted suicide. We want to understand why some young people are at higher risk and how a therapy called CAMS (Collaborative Assessment and Management of Suicidality) might help. CAMS involves weekly sessions to support individuals. Participants will be grouped based on their risk: those recently hospitalized for a suicide attempt, those with ongoing suicidal thoughts but no attempts, and healthy individuals with no history of suicidal thoughts. The study aims to find brain markers that could help predict risk and improve treatment. This study is currently unclear on its recruitment status and plans to enroll 60 participants.

Study design
This interventional study will enroll 60 participants across three risk groups. It is not specified if it is randomized or blinded.
What's involved
High-risk participants will start weekly CAMS sessions immediately as inpatients and continue them weekly after discharge as outpatients. The study involves neuroimaging and clinical assessments.
Compensation
Not stated in the trial record.
Follow-up
Your suicidality and brain changes (MRS) will be measured at 5 years after the start of the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07568054

Neural Correlates of Suicidal Behavior in Youth

Not Yet Recruiting
NAAges 14–24InterventionalHealth services
The Cleveland Clinic
~60 participants
Updated 2026-09-03 on ClinicalTrials.gov
What's tested:CAMS

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
MRS & suicidality
Measured over 5 years

Conditions

Suicidal Ideation
Suicide Attempt
Suicidal Behavior
Depression / Major Depressive Disorder
Hopelessness
Neurobiological

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NCT07568054

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • The Cleveland Clinic

    Cleveland, Ohiostudy coordinator listed

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Tatiana Falcone, M.D. · PRINCIPAL_INVESTIGATOR · The Cleveland Clinic

Who to contact

Christina A Deisz, LISW-S
[email protected]
(440) 225-6193
Email the study team

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Eligibility criteria

Inclusion

Subjects must be 14-24 years old
Subjects must be:
High Risk Subjects: Psychiatrically admitted due to a suicide attempt or history of 2 previous suicide attempts
Medium Risk Subjects: Suicide ideation for the past year with no suicide attempt
Minimal Risk Subjects: No previous history of suicidal ideation or behavior, not taking any psychiatric history or medication, and no family history of suicide
Subjects must have the ability to understand and the willingness to sign a written informed consent/assent document
Subjects must be English speaking

Exclusion

Subjects with known history of Autism Spectrum Disorder; non-verbal patients
Subjects with moderate or severe intellectual disability (IQ less than 70 and those patients in special education classes full time)
Subjects with Schizophrenia or history of any type of psychosis including mood related psychosis and brief reactive psychosis
Within 6 months before initial screening, urine toxicology positive for phencyclidine, cocaine or amphetamines (subjects prescribed amphetamines for the management of ADHD will not be excluded)
Subjects with a history of moderate or severe substance or alcohol use per DSM-5 criteria in the past 6 months
Subjects who are currently pregnant or breastfeeding
Subjects in custody of Children's Services
Subjects with recent bone, tendon, spine or joint surgery
Subjects with recent metallic dental implants
Subjects weighing less than 30 kg or more than 200 kg

What this trial measures

  • MRS & suicidality5 years

    To investigate the effect of changes in Suicide Status Form (SSF) scores (low severity 1-5 high severity) as a result of CAMS therapy on Glx levels.