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Observational Study on Brain Activity in Rett Syndrome

This observational research study aims to understand how the brain processes sound in individuals with Rett syndrome. If you or a loved one has classic Rett syndrome, confirmed by genetic testing, and are past the regression stage, you might be able to participate. Participants will have a noninvasive electroencephalogram (EEG) recording, which measures brain activity while listening to simple sounds through headphones. Parents or caregivers will also complete questionnaires and an interview about symptoms, communication, daily functioning, and overall health. This study does not test any treatments, but the information gathered could help researchers better understand Rett syndrome and support future research efforts.

Study design
This is an observational study with a planned enrollment of 60 participants. It is not a treatment study and does not involve randomized assignments.
What's involved
You would undergo a single noninvasive EEG recording. Parents or caregivers will complete questionnaires and an interview about the participant's health and symptoms.
Compensation
Not stated in the trial record.
Follow-up
Brain activity will be measured at a single study visit, up to one day.

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NCT07569445

Auditory EEG and Behavioral Assessments in Individuals With Rett Syndrome

Recruiting
Not specifiedAges 2+Observational
University of Rochester
~60 participants
Updated 2026-05-06 on ClinicalTrials.gov
What's tested:Electroencephalogram (EEG) Recording

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Mean Auditory Evoked Response Amplitude Measured by EEG
Measured over Assessed at a single study visit (baseline, up to 1 day)
+1 more outcome measured

Conditions

Rett Syndrome

Explore related trials

HealthyRett SyndromeMECP2 Gene

Where it's being run

1 sites across 1 states
New York1

Who to contact

Jamison Seabury, BS
[email protected]
315-663-4159
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Have a clinical diagnosis of classic Rett syndrome
Have a pathogenic MECP2 genetic variant confirmed via genetic testing
Are past the clinical regression stage
Are within the eligible age range for the study (2 years or older)
Are able to tolerate the noninvasive EEG recording
Parent or caregiver is willing and able to provide parental permission and complete questionnaires and interviews
Neurologically healthy individuals ages 2 years or older
Are able to tolerate the noninvasive EEG recording

Exclusion

Experiences hearing impairment or hearing loss
Presence of medical conditions that would prevent safe participation in EEG recording
Inability to tolerate EEG procedures
Any condition that in the opinion of the investigator would interfere with study participation or data quality
Experiences hearing impairment or hearing loss
Medical history of genetic, neurological, or psychiatric disorders
History of special education services
Inability to tolerate EEG procedures
Any condition that in the opinion of the investigator would interfere with study participation or data quality

What this trial measures

  • Mean Auditory Evoked Response Amplitude Measured by EEGAssessed at a single study visit (baseline, up to 1 day)

    Auditory evoked brain responses will be assessed using noninvasive electroencephalogram (EEG) recordings while participants listen to simple sounds through headphones. The mean amplitude of auditory evoked responses will be derived from EEG recordings to describe auditory processing in individuals with Rett syndrome.

  • Mean Auditory Evoked Response Latency Measured by EEGAssessed at a single study visit (baseline, up to 1 day)

    Auditory evoked brain responses will be assessed using noninvasive electroencephalogram (EEG) recordings while participants listen to simple sounds through headphones. The mean latency of auditory evoked responses will be derived from EEG recordings to describe auditory processing in individuals with Rett syndrome.