A Study Of Synthetic THC And Sleep

{ "A Study of Dronabinol and Sleep Apnea", "This study is looking at whether a synthetic form of THC called Dronabinol can help people with Obstructive Sleep Apnea (OSA) use their CPAP machine more consistently and improve their sleep. Researchers also want to see if Dronabinol, when taken before sleep, can help regulate blood pressure. You might be able to join if you are 21-70 years old, male or female, and have moderate to severe OSA. The study will measure how often you use your CPAP, your apnea-hypopnea index (a measure of breathing pauses during sleep), and your physical activity. The study plans to enroll 72 participants, but its current status is unclear.", "design": "This is an interventional study planning to enroll 72 participants. Participants will receive either Dronabinol or a placebo daily for 6 weeks.", "commitments": "You would take either Dronabinol or a placebo daily for 6 weeks. Your breathing pauses during sleep will be measured at Day 15, Day 29, and Day 42, and your physical activity at the beginning and end of the study.", "compensation": "Not stated in the trial record.", "follow_up": "The study measures outcomes up to Day 42, which is the end of the 6-week treatment period.", }

Study design
Not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07570953

A Study Of Synthetic THC And Sleep

Not Yet Recruiting
PHASE2Ages 21–70InterventionalTreatment
Mayo Clinic
~72 participants
Updated 2026-08-13 on ClinicalTrials.gov
What's tested:DronabinolPlacebo

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of times subjects complete CPAP therapy
Measured over Baseline
+2 more outcomes measured
Obstructive Sleep Apnea
1 sites across 1 states
Minnesota1
  • Virend Somers, M.D., Ph.D. · PRINCIPAL_INVESTIGATOR · Mayo Clinic

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Eligibility criteria

Inclusion

21 - 70 years of age
Biological male or female
AHI between 15 - 50 events/hour
Current or new OSA diagnosis
Established or new (within 1 month) CPAP therapy

Exclusion

BMI \> 35 kg/m2
Diagnosed psychiatric disorders
Hypotension
History of seizures
History of substance abuse or recreational drug use or positive urine drug screen
History of uncontrolled disease including:
Cardiovascular
Pulmonary
Gastrointestinal
Pancreatic
Hepatic
Renal
Hematological
Endocrine (including Type I Diabetes)
Neurological
Urological
Pregnant or breastfeeding
Use of certain antimicrobial, chemotherapeutic, anticoagulant, hypoglycemic, anti-inflammatory, psychotropic, and antihistamine drugs
Prescribed CYP2C9 and/or CYP3A4 inhibitors
Severe OSA that in the investigator's judgment should only begin CPAP treatment
Prior upper airway surgery for snoring or OSA as an adult
Significant defect in nasal patency due to anatomical abnormality or uncontrolled rhinitis
Bariatric surgery within 2 years
Medically managed weight-loss program within 6 months
Noninvasive treatment for OSA within 1 month (self-report)
History of shift work or rotating shifts within 1 month
  • Number of times subjects complete CPAP therapyBaseline

    CPAP therapy is defined as using the therapeutic device for ≥ 4 hours per night

  • Apnea-hypopnea index (AHI)Day 15, Day 29, and Day 42

    Apnea-hypopnea index (AHI) an index used to describe the number of apneas experienced during sleep. It is calculated by (Number of hours of sleep/Number of Apneas or hypopneas). This value will then be graded on a scale from Normal (\<5) to Severe (\>30).

  • International Physical Activity QuestionnaireBaseline and Day 42

    International Physical Activity Questionnaire is a 0-10 visual analog scale to assess self-reported sleep quality