Topical Intranasal Anesthetic Block for Reducing Pain of Botulinum Toxin Injections for Chronic Migraine

This study is looking at ways to reduce the pain from onabotulinumtoxinA (Botox®) injections used for chronic migraine. Researchers want to see if putting a small piece of cotton soaked with 4% lidocaine (a numbing medicine) inside each nostril for 5 minutes before the injections helps more than cotton soaked in saline (salt water). The main goal is to measure how much pain you report from the injections. You may be able to join if you are 18 or older, meet the criteria for onabotulinumtoxinA for chronic migraine, and are scheduled for these injections at the study site. The current status of this study is unclear, and it plans to enroll 18 participants.

Study design
This is an interventional study comparing lidocaine to saline before onabotulinumtoxinA injections. It plans to enroll 18 participants.
What's involved
You would receive onabotulinumtoxinA injections after either lidocaine or saline is applied to your nostrils. Your pain will be measured immediately before and after the procedure, and again 12 weeks later.
Compensation
Not stated in the trial record.
Follow-up
Your pain will be assessed at the time of the procedure and again 12 weeks later.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07571889

Topical Intranasal Anesthetic Block for Reducing the Pain of Botulinum Toxin Injections for Chronic Migraine

Recruiting
NAAges 18+InterventionalPrevention
Association of Migraine Disorders
~18 participants
Updated 2026-05-06 on ClinicalTrials.gov
What's tested:onabotulinumtoxinA prophylaxis with LidocaineOnabotulinumtoxinA prophylaxis with Saline

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Overall patient-reported injection pain
Measured over Immediately before and immediately following the procedure at Study Visit 1 and again 12 weeks later at Study Visit 2.
Pain From onabotulinumtoxinA Injections
1 sites across 1 states
Rhode Island1

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Aged ≥18 years
Any gender
Able to provide informed consent
Meets clinical criteria for onabotulinumtoxinA for chronic migraine (minimum of 2 days of disability per month due to facial or headache pain, or 8 headache days per month, or more than 15 headaches per month)
Scheduled for modified PREEMPT injections at the clinical site

Exclusion

Aged \< 18 years
Trigeminal neuralgia, cluster headache, or other primary headache disorders as dominant diagnosis
Not able to provide informed consent
Known allergy/hypersensitivity to lidocaine or amide anesthetics
Pregnancy/lactation
Inability to tolerate intranasal nasal cotton pledgets
Significant nasal pathology at placement site
  • Overall patient-reported injection painImmediately before and immediately following the procedure at Study Visit 1 and again 12 weeks later at Study Visit 2.

    Overall patient-reported injection pain \[0 (no pain) -10 (worse pain possible) Likert/Numeric Rating Scale\] between 4% lidocaine versus 0.9% saline.