Advanced Imaging for Interstitial Lung Disease and Pulmonary Fibrosis

This study is looking at how immunosuppression treatment affects individuals with certain types of interstitial lung disease (ILD), which is a group of lung conditions that cause scarring of the lungs. Researchers will use advanced imaging techniques, specifically [68Ga]CBP8 PET scans and Gadoterate Meglumine DCE-MRI scans, to measure active collagen deposition (scarring) and tissue injury. The goal is to see if immunosuppression treatment changes these measurements over 12 weeks. You may be able to join if you are 18-80 years old, have chronic hypersensitivity pneumonitis, connective tissue-associated ILD, or undifferentiated ILD, and are starting immunosuppression treatment with mycophenolate mofetil, mycophenolate sodium, and/or prednisone. The study aims to enroll 15 participants, but its current status is unclear.

Study design
This is an interventional study planning to enroll 15 participants. It will assess the effects of immunosuppression treatment on specific imaging measurements.
What's involved
Participants will undergo [68Ga]CBP8 PET and DCE-MRI scans before starting treatment and again 12 weeks later. They will also receive single intravenous injections of [68Ga]CBP8 and Gadoterate Meglumine during these imaging procedures.
Compensation
Not stated in the trial record.
Follow-up
Measurements will be taken from baseline to 12 weeks after treatment initiation.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07572383

Advanced Imaging to Assess the Effect of Immunosuppression on Progressive Fibrosis

Recruiting
PHASE2Ages 18–80InterventionalDiagnostic
Peter Caravan
~15 participants
Updated 2026-07-14 on ClinicalTrials.gov
What's tested:[68Ga]CBP8Gadoterate Meglumine

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in SUVmax25 over the entire lungs
Measured over From baseline to 12 weeks
+1 more outcome measured
Interstitial Lung Disease
Pulmonary Fibrosis
1 sites across 1 states
Massachusetts1
  • Sydney Montesi, MD · PRINCIPAL_INVESTIGATOR · Massachusetts General Hospital

Opens a ready-to-send draft in your own email app — review before sending.

  • Change in SUVmax25 over the entire lungsFrom baseline to 12 weeks

    Changes in lung collagen uptake will be measured using the PET probe \[68\]Ga-CBP8. Measurements will be made using the mean of the upper quartile of standardized uptake values (SUVmax25). Primary \[68Ga\]CBP8-PET outcome.

  • Change in the rate of contrast washin (kwashin) over the entire lungsFrom baseline to 12 weeks

    Changes in rate of contrast washin will be measured using dynamic-contrast enhanced MRI. Primary DCE-MRI outcomes.