This study is looking at whether adding tirzepatide (a medication) after surgery to remove an adrenal gland (adrenalectomy) can help people with Mild Autonomous Cortisol Secretion (MACS) improve their health. MACS is when an adrenal gland makes too much cortisol, which can lead to high blood pressure, diabetes, and weight gain. Even after surgery, some people still have these problems. This study will compare patients who have adrenalectomy alone to those who also receive tirzepatide for 12 months. Researchers will primarily look at changes in blood pressure, but also at weight, blood sugar, and quality of life. You might be able to join if you are an adult with MACS, high blood pressure, a BMI of 27 or higher, and are having or have had adrenalectomy. The current status of this study is unclear, and it plans to enroll 34 participants.

Study design

This is an interventional, randomized study. About 34 adult participants will be randomly assigned to one of two groups after surgery.

What's involved

Participants will receive either standard post-operative care or standard care plus tirzepatide for 12 months. Tirzepatide will start at a low dose and may be increased every 4 weeks based on your tolerance.

Compensation

Not stated in the trial record.

Follow-up

Your blood pressure will be measured at the beginning of the study and again after 12 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.