Whole Versus Partial Gland Boost During Prostate SBRT

This study is for men with prostate cancer (prostate adenocarcinoma) who are considering a type of radiation therapy called stereotactic body radiotherapy (SBRT). Researchers want to see if boosting the radiation dose to the entire prostate gland or only to the main tumor (dominant intra-prostatic lesion, DIL) makes a difference in side effects. You would receive SBRT, with one of these two boost methods. The main goal is to compare how often patients experience moderate to severe urinary or digestive side effects between 6 months and 2 years after treatment. This study is currently recruiting and plans to enroll 186 participants.

Study design
This is a phase 2/3 randomized study involving 186 participants. You would be randomly assigned to one of two treatment groups.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 5 years after completing treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07574489

Whole Versus Partial Gland Boost During Prostate SBRT

Not Yet Recruiting
PHASE2Ages 19+InterventionalTreatment
University of Nebraska
~186 participants
Updated 2026-06-29 on ClinicalTrials.gov
What's tested:Prostate stereotactic body radiotherapy with whole gland boostProstate stereotactic body radiotherapy with DIL boost

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Grade 2 or Higher Chronic Genitourinary Toxicity
Measured over From 6 months post-treatment to 2 years post-treatment
+1 more outcome measured
Prostate Cancer
Prostate Adenocarcinoma
1 sites across 1 states
Nebraska1
  • Michael Baine, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Nebraska medicine

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  • Grade 2 or Higher Chronic Genitourinary ToxicityFrom 6 months post-treatment to 2 years post-treatment

    Cumulative incidence of grade 2 or higher chronic genitourinary (GU) toxicities assessed using the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0

  • Grade 2 or Higher Chronic Gastrointestinal ToxicityFrom 6 months post-treatment to 2 years post-treatment

    Cumulative incidence of grade 2 or higher chronic gastrointestinal (GI) toxicities assessed using the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0