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Right Ventricular Response to Exercise in COPD Patients

This study aims to understand how the right side of your heart (right ventricle) responds to exercise if you have chronic obstructive pulmonary disease (COPD). Researchers want to identify different patterns of heart function during rest and exercise to help find better treatments for COPD patients in the future. You may be able to join if you are at least 40 years old and have COPD. The study will measure how well your right ventricle contracts using an echocardiogram (a type of ultrasound for the heart). The current recruitment status is unclear.

Study design
This is an interventional study with a planned enrollment of 60 participants. It will involve studying heart responses to exercise and a subset of participants will receive exercise training.
What's involved
Participants will complete cardiopulmonary exercise testing (CPET) and transthoracic echocardiography (TTE) during rest, moderate-, and high-intensity exercise. A subset of 12 participants will complete moderate-intensity interval training 3 times a week for 12 weeks.
Compensation
Not stated in the trial record.
Follow-up
Right ventricular contractility will be measured up to 1 hour after certain procedures. The total follow-up duration for participants is not specified.

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NCT07576894

Right Ventricular Response to Exercise Among Patients With Chronic Obstructive Pulmonary Disease

Recruiting
NAAges 40+InterventionalTreatment
University of Colorado, Denver
~60 participants
Updated 2026-05-08 on ClinicalTrials.gov
What's tested:Exercise training

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Right ventricular contractility measured by transthoracic echocardiography
Measured over Up to 1 hour

Conditions

COPD
Pulmonary Hypertension
Exercise
Right Ventricular (RV) Dysfunction
Exercise Training

Explore related trials

Chronic Obstructive Pulmonary DiseasePulmonary HypertensionRight Ventricular Dysfunction

Where it's being run

1 sites across 1 states
Colorado1

Study leadership

  • Lindsay Forbes, MD · PRINCIPAL_INVESTIGATOR · University of Colorado, Denver

Who to contact

Lindsay Forbes, MD
[email protected]
(303)724-4020
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

COPD (determined by ratio of forced expiratory volume in 1 second to forced vital capacity \[FEV1/FVC\] \<0.7)
Age \>= 40 years

Exclusion

Exacerbation of COPD in the 3 months prior to enrollment
Change in COPD therapy in the 3 weeks prior to enrollment
Requirement of \>6 LPM supplemental oxygen at rest
Requirement of \>10 LPM supplemental oxygen with exertion
Active/uncontrolled cardiovascular disease (e.g. hypertension with blood pressure \>150/100 despite antihypertensives; coronary artery disease with angina; left ventricular ejection fraction ≤40%; uncontrolled arrhythmia; pulmonic, mitral or aortic valvular abnormality greater than mild in severity; tricuspid regurgitation greater than moderate in severity)
Volume overload (jugular vascular distension or greater than trace peripheral edema)
World Health Organization Functional Class IV
Known pulmonary hypertension with mean pulmonary artery pressure \>45 mmHg
Untreated severe obstructive sleep apnea and/or obesity hypoventilation syndrome
Active malignancy (other than skin)
Medical conditions that limit exercise on an upright stationary bicycle (e.g. severe osteoarthritis, imbalance/gait instability, etc.)
Pregnancy
Body mass index \<18 or \>35
Hematocrit \<25% or \>55%
For subset undergoing right heart catheterization, chronic anticoagulation that is unable to be held for the study visit
For subset undergoing right heart catheterization or exercise training, forced expiratory volume in 1 second of \<20%
For exercise training, already engaged in routine exercise training (\>30 minutes at \>3 METs 3 times/week or more)
For exercise training, inability to complete initial in-person exercise training sessions for approximately 35 minutes 3x/week for 3 weeks (followed by exercise training sessions with an option for hybrid remote/in-person participation)
For exercise training with an option for hybrid remote exercise training, any medical conditions which threaten the safety of remote exercise training (e.g. imbalance/gait instability, etc.).

What this trial measures

  • Right ventricular contractility measured by transthoracic echocardiographyUp to 1 hour

    Global longitudinal strain, measured in absolute percent