Portable MRI for Pediatric Hypoxic Ischemic Brain Injury

This study is looking at a new way to detect brain injuries in children using a portable MRI (magnetic resonance imaging) machine. This special MRI machine can be brought right to a child's bedside in the intensive care unit (ICU), which is safer and easier than moving very sick children to a standard MRI. The study will compare the images from this portable MRI to images from regular MRIs or CT scans to see how well it finds acute (sudden) brain injuries caused by a lack of oxygen (hypoxic ischemic brain injury). We want to see if this portable MRI can accurately diagnose these injuries in children aged 0-17 years who are in the ICU and suspected of having this type of brain injury. The goal is to understand how this portable MRI can best be used in hospitals for children.

Study design
This is an interventional study planning to enroll 200 participants. It will compare the portable MRI to standard imaging methods.
What's involved
If you participate, your child will have a portable MRI at their bedside within 24 hours of a standard MRI or head CT. Any leftover blood or spinal fluid samples from routine clinical tests may also be collected.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome for this study is measured during intensive care admittance, with an average of 1 month.

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NCT07577336

Portable MRI for Pediatric Hypoxic Ischemic Brain Injury

Recruiting
NAUp to 17InterventionalDiagnostic
Children's Mercy Hospital Kansas City
~200 participants
Updated 2026-07-08 on ClinicalTrials.gov
What's tested:Portable MRIScavenged Sample Collection

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Determine the sensitivity and specificity of pMRI for detection of acute pediatric focal ischemic brain injuries.
Measured over During intensive care admittance, an average of 1 month
Acute Brain Injury
Hypoxia, Brain
Ischemia, Brain
Brain Injuries
Trauma, Brain
Stroke
1 sites across 1 states
Missouri1
  • Jessica S Wallisch, MD · PRINCIPAL_INVESTIGATOR · Children's Mercy Kansas City

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Eligibility criteria

Inclusion

Patients hospitalized in the Pediatric Intensive Care Unit, Cardiac Intensive Care Unit, or the Neonatal Intensive Care Unit
Ages 0-17 years at study enrollment
Acute neurologic deficit suspected secondary to Hypoxic Ischemic Brain Injury (HIBI) or patients at high risk for HIBI

Exclusion

Pregnancy
Active implants such as
Pacemaker
Implanted defibrillator
Implanted insulin pump
Deep brain stimulator
Vagus nerve stimulator
Cochlear implant
Programmable shunt
MRI incompatible surgical hardware (e.g., staples, screws, etc.)
Metal-containing tattoos or permanent make-up on head or neck
Suspected metal in eye, e.g.,
Former or current welders, metal workers, or individuals with a metal injury
Metal shrapnel
  • Determine the sensitivity and specificity of pMRI for detection of acute pediatric focal ischemic brain injuries.During intensive care admittance, an average of 1 month

    Perform pMRI on pediatric ICU patients within +/- 24 hours of a clinically obtained, conventional MRI. Compare detection rates and severity of ischemia and cerebral edema by pMRI vs conventional MRI to determine sensitivity and specificity.