The NATURAL Study: Diagnosing Abdominal Pain with RNA Levels

The NATURAL Study is looking at a new blood test called TruNAV to help doctors diagnose the cause of abdominal pain. TruNAV measures specific RNA markers in your blood that show if your body is fighting an infection. This study aims to see if TruNAV can accurately tell if you have an infection in your abdomen, like appendicitis or kidney infection. Researchers want to see if this test can be more than 90% accurate in ruling out these infections. You might be able to join if you are over 7 years old, have abdominal pain that isn't from an injury, and doctors suspect you might have an abdominal infection. The study's success will be measured by how well TruNAV's results match what doctors ultimately diagnose. The current recruitment status is unclear.

Study design
This is an observational study, meaning researchers will collect information without giving you a specific treatment. It plans to include 1000 participants.
What's involved
You would have blood drawn for the TruNAV test. Doctors will also collect information about your health for up to 30 days after your initial visit.
Compensation
Not stated in the trial record.
Follow-up
Your clinical assessment of infection will be followed for up to 30 days after your initial visit.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07579312

Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL Study

Recruiting
Not specifiedAges 7+Observational
True Bearing Diagnostics, Inc.
~1,000 participants
Updated 2026-05-12 on ClinicalTrials.gov
What's tested:TruNAV, an RNA-based blood test for host immune activation by infections

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Agreement to Clinical Adjudication of Infection
Measured over The clinical assessment of infection includes up to 30 days of relevant data after the initial patient visit.
Intra Abdominal Infections
Appendicitis Acute
Pyelonephritis
Diverticulitis
Epiploic Appendagitis
1 sites across 1 states
District of Columbia1
  • Aamir Ali, M.D. · PRINCIPAL_INVESTIGATOR · True Bearing Diagnostics, Inc.

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  • Agreement to Clinical Adjudication of InfectionThe clinical assessment of infection includes up to 30 days of relevant data after the initial patient visit.

    The primary outcome is the agreement (concordance) of the experimental TruNAV blood test with the clinically adjudicated diagnosis of intraabdominal infection, such as appendicitis.