Study on Spasticity in Spinal Cord Injury Using Acute Intermittent Hypoxia
This study is looking at how a breathing intervention called Acute Intermittent Hypoxia (AIH) affects spasticity (muscle tightness) in people with incomplete spinal cord injuries (SCI). AIH involves breathing air with lower oxygen levels for 60 seconds, then regular air for 60 seconds, and this is repeated. Researchers want to see if this intervention changes the reflex threshold of the biceps muscle, which would tell them if spasticity increases. You might be able to join if you are at least 18 years old, have a non-progressive spinal cord injury from C1-C8 that happened at least 6 months ago, and have measurable spasticity. The study is currently unclear on its recruitment status and plans to enroll 10 participants.
- Study design
- This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 10 participants.
- What's involved
- Participants will undergo an Acute Intermittent Hypoxia (AIH) session. Vital signs will be monitored during the session, and a reflex indentation threshold will be measured on Day 1 of the intervention.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoint, change in reflex indentation threshold, is measured at Day 1 of the intervention. Further follow-up is not specified.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Spasticity in SCI Following Acute Intermittent Hypoxia
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- William Z Rymer, MD, PhD · PRINCIPAL_INVESTIGATOR · Shirley Ryan AbilityLab
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Change in reflex indentation thresholdDay 1 of Intervention
Similar to a tendon tap that a doctor may perform, this study uses an automated tendon tapper to measure the level of indentation needed to elicit a reflex in the bicep muscle. The aim is to observe any changes in reflex threshold following the AIH intervention