Study on Spasticity in Spinal Cord Injury Using Acute Intermittent Hypoxia

This study is looking at how a breathing intervention called Acute Intermittent Hypoxia (AIH) affects spasticity (muscle tightness) in people with incomplete spinal cord injuries (SCI). AIH involves breathing air with lower oxygen levels for 60 seconds, then regular air for 60 seconds, and this is repeated. Researchers want to see if this intervention changes the reflex threshold of the biceps muscle, which would tell them if spasticity increases. You might be able to join if you are at least 18 years old, have a non-progressive spinal cord injury from C1-C8 that happened at least 6 months ago, and have measurable spasticity. The study is currently unclear on its recruitment status and plans to enroll 10 participants.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 10 participants.
What's involved
Participants will undergo an Acute Intermittent Hypoxia (AIH) session. Vital signs will be monitored during the session, and a reflex indentation threshold will be measured on Day 1 of the intervention.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, change in reflex indentation threshold, is measured at Day 1 of the intervention. Further follow-up is not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07583498

Spasticity in SCI Following Acute Intermittent Hypoxia

Recruiting
NAAges 18+InterventionalDiagnostic
Zev Rymer
~10 participants
Updated 2026-05-13 on ClinicalTrials.gov
What's tested:Acute Intermittent Hypoxia (AIH)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in reflex indentation threshold
Measured over Day 1 of Intervention
Spinal Cord Injuries (SCI)
1 sites across 1 states
Illinois1
  • William Z Rymer, MD, PhD · PRINCIPAL_INVESTIGATOR · Shirley Ryan AbilityLab

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Eligibility criteria

Inclusion

Age \>= 18
Non-progressive spinal Cord injury at least 6 months prior
Level of injury between C1-C8
ISNCSCI ASIA classification C or D
Measurable Spasticity

Exclusion

Pre-existing hypoxic pulmonary disease
Positive Covid-Pneumonia diagnosis within 1 year of visit
Uncontrolled hypertension \>140/90 mmHg
Individuals who are currently pregnant/nursing or planning on becoming pregnant
Individuals with a tracheostomy or who utilize mechanical ventilation
A botulinum toxin injection to upper extremity musculature within the past 3 months
Currently taking Baclofen
Congestive Heart Failure
Cardiac arrhythmias
Uncontrolled diabetes mellitus
Chronic obstructive pulmonary disease
Emphysema
Severe Asthma
Previous myocardial infarction
Carotid/intracerebral artery stenosis
Orthopedic injuries or surgeries that impact the ability to use the upper extremity
History of Epilepsy
  • Change in reflex indentation thresholdDay 1 of Intervention

    Similar to a tendon tap that a doctor may perform, this study uses an automated tendon tapper to measure the level of indentation needed to elicit a reflex in the bicep muscle. The aim is to observe any changes in reflex threshold following the AIH intervention