Observational Study on Chemotherapy Response in Gastric Cancer

This study is looking at how well people with stage II or III gastric (stomach) cancer respond to standard 5-FU-based adjuvant chemotherapy after surgery. Researchers are analyzing genetic information from tumor tissue to create a model that can predict who will benefit most from this treatment. The goal is to better understand why some patients respond well and others don't, which could help doctors make more informed decisions about your care. To join, you must have stage II or III gastric cancer, have had surgery, received 5-FU-based chemotherapy, and have tumor tissue available for analysis. The study is trying to enroll 329 participants, but its current status is unclear. Success for this study means developing a model that can accurately predict treatment response based on whether cancer returns within three years after surgery.

Study design
This is an observational study, meaning no new treatments are given. Researchers are studying existing patient data and tissue samples.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants' treatment response will be measured at 3 years after surgery to see if their cancer has returned.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07587229

Alternative Splicing Based Prediction of Chemotherapy Response in Gastric Cancer

Recruiting
Not specifiedAges 18+Observational
City of Hope Medical Center
~329 participants
Updated 2026-05-14 on ClinicalTrials.gov
What's tested:Observational study (no intervention)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Treatment response based on 3-year recurrence-free survival
Measured over 3 years after surgery
Gastric Cancer
1 sites across 1 states
California1

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Pathologically confirmed stage II or III gastric cancer
Underwent curative surgical resection
Received 5-FU-based adjuvant chemotherapy
Availability of tumor tissue samples for analysis

Exclusion

History of other malignancies
Inadequate or poor-quality tissue samples (e.g., contamination)
  • Treatment response based on 3-year recurrence-free survival3 years after surgery

    Treatment response was defined based on recurrence-free survival (RFS). Patients who developed recurrence within 3 years after curative surgery were classified as non-responders, whereas those without recurrence were classified as responders.