Back to search results

Skin Substitutes vs. Secondary Intention Healing for Mohs Surgery Wounds

This study is comparing two ways to help wounds heal after Mohs micrographic surgery (a precise surgical technique used to treat skin cancer). You would either receive a special wound-healing material called a skin substitute (like an acellular dermal matrix or fish-skin xenograft) or your wound would heal naturally, which is called secondary intention healing. Researchers want to see which method leads to better cosmetic (appearance) healing after 12 weeks. This study is for adults aged 18 and older who are having Mohs surgery and whose wounds are suitable for this type of healing. The study is currently unclear on its recruitment status.

Study design
This is a randomized-controlled study involving 50 participants. Participants will be randomly assigned to one of two groups.
What's involved
You would need to be able to do daily wound care and attend follow-up visits. You would also need to agree to standardized medical photography.
Compensation
Not stated in the trial record.
Follow-up
Your cosmetic outcome will be assessed at 12 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07587749

Skin Subs vs Secondary Intention

Not Yet Recruiting
PHASE4Ages 18+InterventionalTreatment
Baylor Research Institute
~50 participants
Updated 2026-05-14 on ClinicalTrials.gov
What's tested:Skin SubstituteSecondary Intention Healing

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Cosmetic Outcome Assessments
Measured over 12 weeks

Conditions

Skin Substitutes
Secondary Intention Healing
Skin Cancer Healing

Explore related trials

Malignant Skin Neoplasm

NCT07587749

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Baylor University Medical Center

    Dallas, Texasno site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Stan Tolkachjov, MD · PRINCIPAL_INVESTIGATOR · Baylor Scott and White Health

Who to contact

Umer Nadir, MD
[email protected]
214-820-2361
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Want this trial checked against your situation?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Adults 18 and older undergoing Mohs micrographic surgery
Wounds deemed clinically appropriate for secondary intention healing
Ability to adhere to daily wound care and follow-up visits
Willingness to consent to standardized medical photography

Exclusion

Wounds requiring flap or graft reconstruction for structural/functional reasons
Active wound infection at time of reconstruction
Known allergy to any component of the skin substitute
Severe immunosuppression in which either approach may pose undue risk

What this trial measures

  • Cosmetic Outcome Assessments12 weeks

    Compare cosmetic outcomes at 12 weeks between wounds treated with (1) a skin substitute and (2) secondary intention healing alone. This will be done by a group of blinded independent reviewers using standardized photographs and the Patient and Observer Scar Assessment Scale (POSAS), which evaluates scar quality using a scale of 1-10, where 1 is "like normal skin" and 10 is the "worst imaginable".