Abaloparatide for Bone Quality in Lumbar Degenerative Disease

This study is looking at how a medication called abaloparatide affects bone quality in people with osteoporosis (a condition where bones become weak and brittle) who are having spinal fusion and decompression surgery for lumbar degenerative disease (problems with the lower back). Researchers want to see if abaloparatide improves bone density, as measured by a special score called VBQ, and if it helps reduce problems after surgery, like complications with the spinal hardware. You might be able to join if you are 50 or older, have osteoporosis based on certain criteria (like a fragility fracture or a low T-score), and are scheduled for this type of back surgery. The study aims to enroll 60 participants. The current status of the study is unclear.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 60 participants.
What's involved
Participants will receive 3-6 months of abaloparatide treatment and will be trained on how to apply it. They will also have presurgical assessments.
Compensation
Not stated in the trial record.
Follow-up
Bone quality will be measured at 6 weeks post-operation.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07587775

The Effect of Osteoporotic Medications on Vertebral Bone Quality Score

Enrolling by Invitation
PHASE2Ages 50+InterventionalTreatment
State University of New York at Buffalo
~60 participants
Updated 2026-07-23 on ClinicalTrials.gov
What's tested:Abaloparatide

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Improvement in Bone Quality
Measured over 6 weeks post-op
+11 more outcomes measured
Lumbar Degenerative Disease
1 sites across 1 states
New York1

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Diagnosis of Osteoporosis based on the following criteria:
Fragility fracture (low trauma fracture similar to a fall from a standing position except for fracture to the skull, face, fingers, and toes)
T score \<-2.5
T-score -1 to -2.5 with a high FRAX or high TBS adjusted FRAX (with a 10-year probability of major osteoporotic fracture ≥20% or a 10-year probability of hip fracture ≥3%)
Fulfill criteria for treatment with anabolic therapy, as outlined in the American Association of Clinical Endocrinologist guidelines for the diagnosis and treatment of postmenopausal osteoporosis in women and Evidence-Based Guideline for the management of osteoporosis in men.
Lumbar Degenerative Disease as evidenced by a diagnosis of spondylosis, spondylolisthesis, degenerative disc disease with spinal stenosis, and degenerative scoliosis
Have or be willing to have a DEXA scan, lumbar MRI, and lumbar CT within 3 months of the start of Abaloparatide
If on thyroid hormone replacement, having been on it for at least 6 months

Exclusion

Previous lumbar surgery
Past medical history of: sarcoma, including osteosarcoma, paget disease or other skeletal malignancies, unexplained elevations of alkaline phosphatase, prior external beam radiation, and pre-existing hypercalcemia
Diagnosis of secondary osteoporosis
Vitamin D deficit
History of prior treatment with TPTD and ABL
  • Improvement in Bone Quality6 weeks post-op

    Improvement in bone quality, using Vertebral Bone Quality

  • Improvement in Bone Quality6 weeks post-op

    Improvement in bone quality, using Hounsfield Units

  • Improvement in Bone Quality6 weeks post-op

    Improvement in bone quality, using DEXA (Dual-Energy X-ray ABsorptiometry)

  • Improvement in Bone Quality6 months post-op

    Improvement in bone quality, using Vertebral Bone Quality

  • Improvement in Bone Quality6 months post-op

    Improvement in bone quality, using Hounsfield Units

  • Improvement in Bone Quality6 months post-op

    Improvement in bone quality, using DEXA (Dual-Energy X-ray ABsorptiometry)

  • Improvement in Bone Quality12 months post-op

    Improvement in bone quality, using Vertebral Bone Quality

  • Improvement in Bone Quality12 months post-op

    Improvement in bone quality, using Hounsfield Units

  • Improvement in Bone Quality12 months post-op

    Improvement in bone quality, using DEXA (Dual-Energy X-ray ABsorptiometry)

  • Improvement in Bone Quality24 months post-op

    Improvement in bone quality, using Vertebral Bone Quality

  • Improvement in Bone Quality24 months post-op

    Improvement in bone quality, using Hounsfield Units

  • Improvement in Bone Quality24 months post-op

    Improvement in bone quality, using DEXA (Dual-Energy X-ray ABsorptiometry)